Results 51 to 60 of about 2,552,787 (292)
PlaNext, 2017 Through the provision of digital tools, government institutions aim to counter the growing alienation of citizens towards institutional politics and overcome traditional barriers of participation.
Sarah-Kristin Thiel
doaj
Historical trends in Hawaiian game harvest and hunter participation in Hawai'i from 1946-2008.
PLoS ONE, 2019 At present, 21 game species have been successfully established in Hawai'i for the purpose of recreational and subsistence hunting. However, it is unknown how these management efforts have affected hunting and recreation trends in Hawai'i and how the ...
Christopher A Lepczyk, Deidre J Duffy
doaj +1 more source
Defining a Conceptual Framework for a Toolkit to Game Design
Journal of Digital Media & Interaction, 2021 Seeking to capitalize the interest of younger audiences in game creation activities, the Gamers4Nature project aims to develop a toolkit designed to support game design by allowing the manipulation of the several elements that compose a game.
Mónica Aresta +3 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Hedonic valuation of online game participation
Proceedings of the 14th Annual International Conference on Electronic Commerce, 2012 We use hedonic valuation to establish a basis for valuing the time a user participates in an online gaming community. We distinguish between utilitarian and hedonic value. Our application involves elements of both utilitarian and hedonic value, however, the latter is much more important.
KAUFFMAN, Robert J. +2 more
openaire +3 more sources
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
IAP2 Spectrum of Public Participation
, 2007 Chart presenting the spectrum of public ...
International Association of Public Participation
core +1 more source
On Some Myths about Sequenced Common-valued Auctions [PDF]
, 1998 Equilibria are constructed for classes of game models of sequenced second-price auctions having identical common-valued objects. In some of these the equilibrium price falls on average, and in others the seller loses on average by committing to announce ...
Frutos, María Ángeles de +1 more
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source