Results 41 to 50 of about 57,701 (263)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The Impact of Nintendo's "For Men" Advertising Campaign on a Potential Female Market
Eludamos, 2008 In order to emphasize the maturation of their hand-held console and increase its appeal to an adult market, Nintendo's UK advertising campaign for the Game Boy Advance SP drew explicitly upon Œlad' culture and a tongue-in-cheek appropriation of cologne ...
Gareth Schott, Siobhan Thomas
doaj +1 more source
A Novel Joint Dataset and Incentive Management Mechanism for Federated Learning Over MEC
IEEE Access, 2022 In this study, to reduce the energy consumption for the federated learning (FL) participation of mobile devices (MDs), we design a novel joint dataset and incentive management mechanism for FL over mobile edge computing (MEC) systems.
Joohyung Lee, Daejin Kim, Dusit Niyato
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Hedonic valuation of online game participation
Proceedings of the 14th Annual International Conference on Electronic Commerce, 2012 We use hedonic valuation to establish a basis for valuing the time a user participates in an online gaming community. We distinguish between utilitarian and hedonic value. Our application involves elements of both utilitarian and hedonic value, however, the latter is much more important.
KAUFFMAN, Robert J. +2 more
openaire +3 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Historical trends in Hawaiian game harvest and hunter participation in Hawai'i from 1946-2008.
PLoS ONE, 2019 At present, 21 game species have been successfully established in Hawai'i for the purpose of recreational and subsistence hunting. However, it is unknown how these management efforts have affected hunting and recreation trends in Hawai'i and how the ...
Christopher A Lepczyk, Deidre J Duffy
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
PlaNext, 2017 Through the provision of digital tools, government institutions aim to counter the growing alienation of citizens towards institutional politics and overcome traditional barriers of participation.
Sarah-Kristin Thiel
doaj
Defining a Conceptual Framework for a Toolkit to Game Design
Journal of Digital Media & Interaction, 2021 Seeking to capitalize the interest of younger audiences in game creation activities, the Gamers4Nature project aims to develop a toolkit designed to support game design by allowing the manipulation of the several elements that compose a game.
Mónica Aresta +3 more
doaj +1 more source