Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Subaltern imaginaries of localism: constructions of place, space and democracy in community-led housing organisations. [PDF]
, 2013 The localism strategies of the UK government provide a suite of ‘rights’ for community organisations that licence place-based political imaginaries with the intent to construct the community as a proxy for a smaller state.
Bradley, Q
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Explainable AI in education: A multi-stakeholder approach to transparency and ethical practice
IUL ResearchIntegrating AI into education makes explainability an ethical imperative. This analysis examines competency requirements for 5 stakeholder groups – learners, educators, parents, system leaders, and developers – while evaluating capacity-building ...
Jessica Niewint-Gori
doaj +1 more source
How to overcome the governance challenges of implementing NREGA [PDF]
Large-scale social safety net programs such as India s National Rural Employment Guarantee Act (NREGA) are difficult to implement due to governance challenges related to elite capture, leakages, and corruption.
Birner, Regina +5 more
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The Impact of Participatory Governance on Regional Development Pathways: Citizen-driven Smart, Green and Inclusive Urbanism in the Brainport Metropolitan Region [PDF]
, 2020 Christiane Gebhardt
openalex +1 more source
Participatory governance in megaprojects: the Lyon–Turin high-speed railway among structure, agency, and democratic participation [PDF]
, 2023 Giovanni Esposito +2 more
openalex +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
E-Governance Service System Readiness Assessment Framework from CSCW’s Perspective
Mehran University Research Journal of Engineering and Technology, 2019 Growing E-Participation services compel democratic governments to re-examine their E-Governance service system readiness assessment models with respect to their usability, effectiveness and participatory governance. In practice, the open government data,
Ashraf Ali Waseem +2 more
doaj +1 more source