Results 121 to 130 of about 1,348,580 (296)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

EFIGE: a conceptual model for integrating environmental education, social participation and environmental governance for sustainability

EQA
Environmental challenges increasingly require approaches capable of integrating education, social participation, and governance mechanisms to promote sustainability.
Norma Barbado, Cristiano Trindade De Angelis   +1 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Going upstream: a pluri-ontological analysis and proposal for Brazilian participatory water governance

Ecosystems and People
Despite the growing emphasis on ontological pluralism in environmental policy debates, innovation within national state environmental governance and management remains limited.
Thomas Rickard, David Ludwig, Raoni Rajão   +2 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Voice, Choice, and Governance: The Case of Tanzania's Fairtrade Coffee Co-operatives [PDF]

, 2014
PhDThe copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the author.This research contributes to the growing body of knowledge about Fairtrade’s ...
Sutton, Shannon
core   +1 more source

Empowerment or legitimation? The Angolan Conselhos de Auscultação e Concertação Social

Revista Iberoamericana de Estudios de Desarrollo, 2012
The Conselhos de Auscultação e Concertação Social (CACS) of Angola are spaces of participatory governance, where local authorities have to consult and be accountable to society.
Hueso González, Andrés
doaj  

Smarter Cities, Stronger Heritage: Toward Participatory and Knowledge-Driven Governance for Cultural Preservation in Morocco

Engineering Proceedings
This paper explores how Smart Urban Governance, Smart Knowledge Management (Smart KM), and participatory digital tools can reshape cultural heritage rehabilitation in Morocco. Using a qualitative, multi-method approach including comparative case studies,
Douae El Hadraoui, Naila Amrous
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Towards good governance at the local level : the role of grassroots institutions [PDF]

governance;Netherlands;voluntary organizations;local government;developing countries;foreign aid;grass roots groups;institution building;participatory ...
Wit, J.W. de
core