Results 121 to 130 of about 952,020 (338)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Reframing brownfield redevelopment through a community participation framework: a comparative review of governance models

Journal of Asian Architecture and Building Engineering
This study offers a comparative conceptual review of brownfield redevelopment (BFR) through the lens of community participation frameworks. Moving beyond traditional scoping reviews, we analyze how participatory models – particularly Arnstein’s Ladder of
Eunki Kang, Yoon-Jeoung Shin, Eun Joo Park   +2 more
doaj   +1 more source

The Role of Participatory Planning and Design in Addressing the UN Sustainable Development Goals

Urban Planning
This editorial explores the role of participatory planning and design in addressing the United Nations Sustainable Development Goals (UN SDGs) within urban, regional, and rural contexts, which is the focus of this thematic issue.
Hilary Davis, Joel Fredericks, Marcus Foth, Glenda Amayo Caldwell, Callum Parker   +4 more
doaj   +1 more source

Towards a multifaceted measure of perceived legitimacy of participatory governance

Governance. An International Journal of Policy, Administration and Institutions, 2023
T. Haesevoets, Arne Roets, Kristof Steyvers, B. Verschuere, Bram Wauters   +4 more
semanticscholar   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Participatory Water Governance and Organisational Change: Implementing the Water Framework Directive in England and Wales

, 2019
Public participation is central to the IWRM discourse and often associated with claims of improved environmental policy outputs and their implementation.
Oliver Fritsch
core   +1 more source

Czech postcommunist trouble with participatory governance. Toward an analysis of the cultural agency of policy discourses

Policy studies, 2019
The article uses the postcommunist context to rethink the argumentative arena of current participatory governance. While citizen empowerment is a crucial component of participatory governance, it has not received much attention in either the policy or ...
Anna P. Durnová
semanticscholar   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Citizens’ deliberations and the EU democratic deficit – Is there a model for participatory democracy? [PDF]

, 2008
There is a longstanding debate on the EU’s democratic deficit. Recently, the EU has responded to this by including the idea of participatory democracy in the Lisbon treaty. This corresponds to first experiments with means for citizens’ participation that
Abels, Gabriele.
core  

In participatory budgeting we trust? Fairness, tactics and (in)accessibility in participatory governance

Local Government Studies, 2019
Participatory budgeting (PB) is a significant innovation in democracy and local development. PB provides the opportunity for citizens to engage in processes of deliberation and decision-making upon the allocation of public funds.
Catherine Wilkinson, J. Briggs, K. Salt, John Vines, Emma Flynn   +4 more
semanticscholar   +1 more source