Results 131 to 140 of about 1,111,775 (322)

Going upstream: a pluri-ontological analysis and proposal for Brazilian participatory water governance

Ecosystems and People
Despite the growing emphasis on ontological pluralism in environmental policy debates, innovation within national state environmental governance and management remains limited.
Thomas Rickard, David Ludwig, Raoni Rajão   +2 more
doaj   +1 more source

ACP-EU Water Facility: Partnerships initiative [PDF]

, 2012
This report evaluates the expected impact of the ACP-EU Water Partnerships programme, and compares it with other international programmes of not-for-profit partnerships for capacity development in the water and sanitation sector.
Hall, David, Lobina, Emanuele
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A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Integration of multi-scale stakes in governance by applying companion modelling to land use foresight [PDF]

, 2009
Decentralization of land use governance creates new challenges for participatory approaches, including the involvement of highly diverse participants and the search for coherence among multiple regulations.
Antona, Martine, Botta, Aurélie, Daré, William's, Leclerc, Grégoire   +3 more
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Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Agricultural strategy development in West Africa: The false promise of participation? [PDF]

"Participatory approaches are an increasingly prominent technique for designing agricultural strategies within Sub-Saharan Africa. However, such approaches are frequently criticized for either not involving enough stakeholders or limiting the scope of ...
Birner, Regina, Resnick, Danielle
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Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Deliberative Visioning: A Critical View Observations From a Scenario Workshop for Water Management in a Greek Island [PDF]

There is a growing policy interest in participatory processes that combine deliberation with futures visioning. The EU Water Framework Directive, with its mandate for participatory long-term river basin plans, contributes to this “futures turn†in ...
Alexandra Mexa, Dionisia Hatzilakou, Eleni Svoronou, Giorgos Kallis, Harry Coccossis   +4 more
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Globalisation, Policy Transfer, and Global Governance: an Assessment in Developing Countries [PDF]

, 2010
Dari perspektif ekonomi politik, globalisasi identik dengan liberalisasi, sedangkan dariperspektif kebijakan publik, globalisasi identik dengan policy transfer.
LAILA KHOLID, LAILA KHOLID
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