Results 61 to 70 of about 773,976 (338)

Ultrastructure of Zika virus particles in cell cultures [PDF]

Memórias do Instituto Oswaldo Cruz, 2016
Zika virus (ZIKV) has infected thousands of Brazilian people and spread to other American countries since 2015. The introduction of ZIKV brought a strong impact to public health in Brazil. It is of utmost importance to identify a susceptible cell line that will enable the isolation and identification of the virus from patient samples, viral mass ...
Barreto-Vieira, Debora Ferreira, Barth, Ortrud Monika, Silva, Marcos Alexandre Nunes da, Santos, Carolina Cardoso, Santos, Aline da Silva, F Filho, Joaquim Batista, Filippis, Ana Maria Bispo de   +6 more
openaire   +4 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

MeV proton acceleration at kHz repetition rate from ultra-intense laser liquid interaction

New Journal of Physics, 2018
Laser acceleration of ions to ≳MeV energies has been achieved on a variety of Petawatt laser systems, raising the prospect of ion beam applications using compact ultra-intense laser technology.
John T Morrison, Scott Feister, Kyle D Frische, Drake R Austin, Gregory K Ngirmang, Neil R Murphy, Chris Orban, Enam A Chowdhury, W M Roquemore   +8 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Quantum radiation reaction in head-on laser-electron beam interaction

New Journal of Physics, 2016
In this paper, we investigate the evolution of the energy spread and the divergence of electron beams while they interact with different laser pulses at intensities where quantum effects and radiation reaction are of relevance.
Marija Vranic, Thomas Grismayer, Ricardo A Fonseca, Luis O Silva   +3 more
doaj   +1 more source

Mitigation of electron cloud effects in the FCC-ee collider

EPJ Techniques and Instrumentation, 2022
Electron clouds forming inside the beam vacuum chamber due to photoemission and secondary emission may limit the accelerator performance. Specifically, the electron clouds can blow up the vertical emittance of a positron beam, through a head-tail-type ...
Fatih Yaman, Giovanni Iadarola, Roberto Kersevan, Salim Ogur, Kazuhito Ohmi, Frank Zimmermann, Mikhail Zobov   +6 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

An investigation of the emittance of escaping fast electron beams from planar and nanowire targets

High Power Laser Science and Engineering
Fast electron generation and transport in high-intensity laser–solid interactions induces X-ray emission and drives ion acceleration. Effective production of these sources hinges on an efficient laser absorption into the fast electron population and ...
E. J. Hume, P. Köster, F. Baffigi, F. Brandi, D. Calestani, G. Cristoforetti, L. Fulgentini, L. Labate, A. Marasciulli, S. Morris, D. Palla, M. Salvadori, M. Villani, L. A. Gizzi, K. L. Lancaster   +14 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source