Results 241 to 250 of about 24,141 (294)

Spatially Profiling Trace Cytokine Signatures From Microscopically Derived Skin Samples to Probe Skin Disease Inflammation

Small Methods, EarlyView.
Inflammatory skin diseases are driven by immune dysregulation and cytokine imbalance. A challenge persists in profiling cytokines in microscopically derived biopsy skin samples due to low protein content. This study introduces a digital SERS immunoassay to simultaneously detect IL‐17A, IL‐22, IL‐23, and TNF at trace concentrations as low as 104 aM. The
Aditya Krishnakumar, Zhen Zhang, Courtney Vedelago, Timothy J. Liu, Yung‐Ching Kao, H. Peter Soyer, Mitchell S. Stark, Snehlata Kumari, Matt Trau, Alain Wuethrich   +9 more
wiley   +1 more source

Advances in proton therapy technology and global clinical applications. [PDF]

Front Oncol
Zhang Q, Yang W, Tan L, Guo X, Wang T, Zhu P, Jing Z, Ma L, Hou J.   +8 more
europepmc   +1 more source

Structural Profiling of Lipid Nanoparticles at Sub‐10 nm Resolution via AF4 Coupled Online to SAXS and SANS

Small Methods, EarlyView.
Dilution‐controlled AF4 coupled with SAXS and, for the first time, SANS enables high‐resolution characterization of non‐spherical lipid nanoparticles. Enhanced scattering contrast and D2O‐based measurements resolve particle features down to ∼5 nm and reveal shape distributions.
Eva Bittrich, Susanne Boye, Zanelle Van Niekerk, Zahn Stanvliet, Arthur Porfetye, Fátima Herranz‐Trillo, Hans Bolinsson, Stefaniya Gaydarova, Christo Tzachev, Anne Martel, Lars Nilsson, Ralf Schweins, Albena Lederer   +12 more
wiley   +1 more source

A prospective risk analysis for the clinical commissioning of a dose-driven continuous scanning proton therapy system. [PDF]

Front Oncol
Herchko S, Liang X, Shen J, Beltran C, Furutani KM.   +4 more
europepmc   +1 more source

SMILE: Extraction‐free submicron‐resolution mapping of lipid chain length and unsaturation by stimulated Raman imaging

VIEW, EarlyView.
In this work, we develop submicron‐resolution mapping of intracellular lipid elements (SMILE) as an extraction‐free vibrational spectroscopic imaging platform based on hyperspectral stimulated Raman scattering microscopy with a spectral analysis pipeline for pixel‐resolved lipid profiling.
Yihui Zhou, Xiangjie Huang, Xingxin Liu, Ling Zhang, Jie Huang, Jing Zhao, Yongqing Zhang, Jin Zhang, Yanqing Gong, Delong Zhang, Hyeon Jeong Lee   +10 more
wiley   +1 more source

Proton beam therapy for patients with distal cholangiocarcinoma: a multicenter prospective registry study (Influence of age factor). [PDF]

J Radiat Res
Yamazaki H, Shibuya K, Kimoto T, Suzuki M, Murakami M, Terashima K, Iizumi T, Wakatsuki M, Ogino T, Takagi M, Araya M, Matsumoto S, Ogino H, Hashimoto T, Hojo H, Fukumitsu N, Yanagi T.   +16 more
europepmc   +1 more source

Design and commissioning of a new synchrotron beamline dedicated to X‐ray footprinting mass spectrometry

Journal of Synchrotron Radiation, EarlyView.
A dedicated beamline at the Advanced Light Source synchrotron has been opened and commissioned for X‐ray footprinting mass spectrometry.The structural biology method of X‐ray footprinting mass spectrometry (XFMS) is available at two national synchrotron beamlines in the USA: one at the Advanced Light Source (ALS) on the West Coast and the other at the ...
Sayan Gupta, Brandon Russell, Line G. Kristensen, Jared de Chant, Anthony Lu, Lieselotte Obst-Huebl, Behzad Rad, James Tyler, Simruthi Subramanian, Savannah Kidd, Sathi Paul, Yan Chen, Christopher J. Petzold, Darren N. Kahan, Shawn M. Costello, Kei Nakamura, Jamie L. Inman, Alastair A. MacDowell, Adrian Spucces, Corie Y. Ralston   +19 more
wiley   +1 more source

Robust Four-Field and Arc LET-Optimized Proton Prostate Cancer Treatment Plans With Urethral Sparing. [PDF]

Int J Part Ther
Vieceli M, Park J, Saki M, Grewal H, Mendenhall NP, Johnson P, Artz M.   +6 more
europepmc   +1 more source

Effect of oxygen and nanoparticles on human skin and colon cells exposed to synchrotron‐based X‐ray FLASH beams

Journal of Synchrotron Radiation, EarlyView.
Most cancer patients will be treated by radiotherapy, and recent findings suggest that delivering radiation at `FLASH' ultra‐high dose rates reduces damage to healthy tissues while still damaging the tumour. This project experimentally validates the reduced healthy tissue damage of FLASH radiotherapy on cells using synchrotron‐based beams, which will ...
Moshi Geso, Matthew Cameron, Tom Ffrench, Helen Forrester, Rod Lynch, Masao Nakayama, William Patterson, Wan Nordiana Rahman, Duncan Butler, Terrence J. Piva   +9 more
wiley   +1 more source

Biologically Effective Dose-Optimized Multi-Intensity-Modulated Proton Therapy: A Biologically Comparable Alternative to Proton Arc Therapy. [PDF]

Int J Part Ther
Shinde N, Zhu Y, Wang W, Li W, Lin Y, Gan GN, Lominska C, Rotondo R, Chen RC, Gao H.   +9 more
europepmc   +1 more source