Results 1 to 10 of about 343,312 (298)

Tumour Therapy with Particle Beams [PDF]

AIP Conference Proceedings, 2000
Photons are exponentially attenuated in matter producing high doses close to the surface. Therefore they are not well suited for the treatment of deep seated tumours. Charged particles, in contrast, exhibit a sharp increase of ionisation density close to
Grupen, C.
core   +5 more sources

Evaluation of in vitro irradiation setup: Designed for the horizontal beamline at the Danish Centre for Particle Therapy [PDF]

Acta Oncologica
Background: Radiobiological experimental setups are challenged by precise sample positioning along depth dose profile, scattering conditions, and practical difficulties that must be addressed in individual designs. The aim of this study was to produce
Anders Tobias Frederiksen, Morten Bjørn Jensen, Per Rugaard Poulsen, Niels Bassler, Brita Singers Sørensen, Mateusz Sitarz   +5 more
doaj   +2 more sources

Spot-scanning proton therapy for targets with adjacent cardiac implantable electronic devices – Strategies for breast and head & neck cancer

Physics and Imaging in Radiation Oncology, 2022
Background and purpose: Cardiac implantable electronic device (CIED) malfunctions can be induced by secondary neutron dose from spot-scanning proton therapy.
Line Bjerregaard Stick, Peter Magnus Trock Lægdsmand, Henrik Laurits Bjerre, Morten Høyer, Kenneth Jensen, Maria Fuglsang Jensen, Mads Brix Kronborg, Birgitte Vrou Offersen, Camilla Jensenius Skovhus Kronborg   +8 more
doaj   +1 more source

Tissue-specific range uncertainty estimation in proton therapy

Physics and Imaging in Radiation Oncology, 2023
Background and Purpose: Proton therapy is sensitive to range uncertainties, which typically are accounted for by margins or robust optimization, based on tissue-independent uncertainties.
Casper Dueholm Vestergaard, Ludvig Paul Muren, Ulrik Vindelev Elstrøm, Jacob Graversen Johansen, Vicki Trier Taasti   +4 more
doaj   +1 more source

Radiobiological model-based approach to determine the potential of dose-escalated robust intensity-modulated proton radiotherapy in reducing gastrointestinal toxicity in the treatment of locally advanced unresectable pancreatic cancer of the head

Radiation Oncology, 2020
Background The purpose of this study was to determine the potential of escalated dose radiation (EDR) robust intensity-modulated proton radiotherapy (ro-IMPT) in reducing GI toxicity risk in locally advanced unresectable pancreatic cancer (LAUPC) of the ...
Vijay P. Raturi, Hidehiro Hojo, Kenji Hotta, Hiromi Baba, Ryo Takahashi, Toshiya Rachi, Naoki Nakamura, Sadamoto Zenda, Atsushi Motegi, Hidenobu Tachibana, Takaki Ariji, Kana Motegi, Masaki Nakamura, Masayuki Okumura, Yasuhiro Hirano, Tetsuo Akimoto   +15 more
doaj   +1 more source

Proton therapy planning and image-guidance strategies within a randomized controlled trial for high-risk prostate cancer

Clinical and Translational Radiation Oncology, 2023
The Danish Prostate Cancer Group is launching the randomized trial, PROstate PROTON Trial 1 (NCT05350475), that compares photons and protons to the prostate and pelvic lymph nodes in treatment of high-risk prostate cancer.
Sofie Tilbæk, Ludvig Paul Muren, Anne Vestergaard, Liliana Stolarczyk, Heidi S. Rønde, Tanja S. Johansen, Jimmi Søndergaard, Morten Høyer, Jan Alsner, Lise Nørgaard Bentzen, Stine Elleberg Petersen   +10 more
doaj   +1 more source

Intrafraction tumor motion monitoring and dose reconstruction for liver pencil beam scanning proton therapy

Frontiers in Oncology, 2023
BackgroundPencil beam scanning (PBS) proton therapy can provide highly conformal target dose distributions and healthy tissue sparing. However, proton therapy of hepatocellular carcinoma (HCC) is prone to dosimetrical uncertainties induced by respiratory
Saber Nankali, Saber Nankali, Esben Schjødt Worm, Jakob Borup Thomsen, Line Bjerregaard Stick, Jenny Bertholet, Morten Høyer, Britta Weber, Britta Weber, Hanna Rahbek Mortensen, Per Rugaard Poulsen, Per Rugaard Poulsen   +11 more
doaj   +1 more source

Dose–Volume and Radiobiological Model-Based Comparative Evaluation of the Gastrointestinal Toxicity Risk of Photon and Proton Irradiation Plans in Localized Pancreatic Cancer Without Distant Metastasis

Frontiers in Oncology, 2020
Background: Radiobiological model-based studies of photon-modulated radiotherapy for pancreatic cancer have reported reduced gastrointestinal (GI) toxicity, although the risk is still high. The purpose of this study was to investigate the potential of 3D-
Vijay P. Raturi, Vijay P. Raturi, Taku Tochinai, Hidehiro Hojo, Toshiya Rachi, Kenji Hotta, Naoki Nakamura, Sadamoto Zenda, Atsushi Motegi, Takaki Ariji, Yasuhiro Hirano, Hiromi Baba, Hajime Ohyoshi, Masaki Nakamura, Masayuki Okumura, Yanping Bei, Tetsuo Akimoto, Tetsuo Akimoto   +17 more
doaj   +1 more source

Dose-response of deformable radiochromic dosimeters for spot scanning proton therapy

Physics and Imaging in Radiation Oncology, 2020
Intrafractional motion and deformation influence proton therapy delivery for tumours in the thorax, abdomen and pelvis. This study aimed to test the dose–response of a compressively strained three-dimensional silicone-based radiochromic dosimeter during ...
Simon V. Jensen, Lia B. Valdetaro, Per R. Poulsen, Peter Balling, Jørgen B.B. Petersen, Ludvig P. Muren   +5 more
doaj   +1 more source

Dosimetric feasibility of moderately hypofractionated/dose escalated radiation therapy for localised prostate cancer with intensity-modulated proton beam therapy using simultaneous integrated boost (SIB-IMPT) and impact of hydrogel prostate-rectum spacer

Radiation Oncology, 2022
Purpose To examine the dosimetric feasibility of hypofractionated/dose escalated radiation therapy in patients with localized prostate carcinoma using simultaneous integrated boost intensity-modulated proton beam therapy (SIB-IMPT) in absence or presence
Dalia Ahmad Khalil, Danny Jazmati, Dirk Geismar, Jörg Wulff, Christian Bäumer, Paul Heinz Kramer, Theresa Steinmeier, Stefanie Schulze Schleitthoff, Sandija Plaude, Martin Bischoff, Stephan Tschirdewahn, Boris Hadaschik, Beate Timmermann   +12 more
doaj   +1 more source