Results 31 to 40 of about 182,390 (296)

Is an Endorectal Balloon Beneficial for Rectal Sparing after Spacer Implantation in Prostate Cancer Patients Treated with Hypofractionated Intensity-Modulated Proton Beam Therapy? A Dosimetric and Radiobiological Comparison Study

Current Oncology, 2023
Background: The aim of this study is to examine the dosimetric influence of endorectal balloons (ERB) on rectal sparing in prostate cancer patients with implanted hydrogel rectum spacers treated with dose-escalated or hypofractionated intensity-modulated
Dalia Ahmad Khalil, Jörg Wulff, Danny Jazmati, Dirk Geismar, Christian Bäumer, Paul-Heinz Kramer, Theresa Steinmeier, Stefanie Schulze Schleithoff, Stephan Tschirdewahn, Boris Hadaschik, Beate Timmermann   +10 more
doaj   +1 more source

Dosimetric Comparison of Treatment Techniques: Brachytherapy, Intensity- Modulated Radiation Therapy, and Proton Beam in Partial Breast Irradiation

, 2015
Purpose: To perform a dosimetric comparison of 3 accelerated partial breast irradiation techniques: catheter-based brachytherapy (BT), intensity-modulated radiation therapy (IMRT), and proton beam therapy (PBT).
Srivastava, Shiv P., Mannina, Edward M. Jr., Das, Indra J., Cox, John A., Hansen, Tara M., Bartlett, Gregory K.   +5 more
core   +1 more source

Benefit of range uncertainty reduction in robust optimisation for proton therapy of brain, head-and-neck and breast cancer patients

Physics and Imaging in Radiation Oncology
Background and Purpose: The primary cause of range uncertainty in proton therapy is inaccuracy in estimating the stopping-power ratio from computed tomography.
Ivanka Sojat Tarp, Vicki Trier Taasti, Maria Fuglsang Jensen, Anne Vestergaard, Kenneth Jensen   +4 more
doaj   +1 more source

Extended Volumetric Follow-up of Juvenile Pilocytic Astrocytomas Treated with Proton Beam Therapy

, 2016
Purpose: To describe volume changes following proton beam therapy (PBT) for juvenile pilocytic astrocytoma (JPA), we analyzed post-PBT magnetic resonance imaging (MRI) to clarify survivorship, response rate, and the concept of pseudoprogression ...
Mannina, Edward M., McMullen, Kevin P., Bartlett, Greg K.   +2 more
core   +1 more source

High-Dose Proton Beam–Based Radiation Therapy in the Management of Extracranial Chondrosarcomas

, 2016
Purpose: Radiation therapy (RT) improves local tumor control in axial chondrosarcomas (CS). It is, however, often difficult to safely deliver the high doses (range, 70.2-77.4 Gy) required for achieving a high likelihood of local control, especially in ...
Lee, Richard Y., Giraud, Christine, Harmon, David, Chen, Yen-Lin E., Jacobson, Alex, Hornicek, Francis J., Choy, Edwin, DeLaney, Thomas F., Bhatt, Aashish D., Nielsen, Petur, Schwab, Joseph H.   +10 more
core   +1 more source

Proton dose calculation on cone-beam computed tomography using unsupervised 3D deep learning networks

Physics and Imaging in Radiation Oncology
Background and Purpose: Poor image quality of cone-beam computed tomography (CBCT) images can hinder proton dose calculation to assess the influence of anatomy changes.
Casper Dueholm Vestergaard, Ulrik Vindelev Elstrøm, Ludvig Paul Muren, Jintao Ren, Ole Nørrevang, Kenneth Jensen, Vicki Trier Taasti   +6 more
doaj   +1 more source

Dosimetric Comparison of Plans for Photon- or Proton-Beam Based Radiosurgery of Liver Metastases

, 2016
Purpose: Radiosurgery treatment of liver metastases with photon beams has been an established method for more than a decade. One method commonly used is the stereotactic body radiation therapy (SBRT) technique.
Ana Ureba, Michael Gubanski, Siegbahn, Albert,, Lind, PA, Pehr A. Lind, Henry, Thomas,, Mondlane, G, Siegbahn, A,, Gracinda Mondlane, Thomas Henry, Gubanski, M,, Henry, T, Albert Siegbahn, Ureba, Ana,, Gubanski, Michael, Ureba, A,, Lind, Pehr A., Mondlane, Gracinda,   +17 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Empirical quenching correction in radiochromic silicone-based three-dimensional dosimetry of spot-scanning proton therapy

Physics and Imaging in Radiation Oncology, 2021
Background and purpose: Three-dimensional dosimetry of proton therapy (PT) with chemical dosimeters is challenged by signal quenching, which is a lower dose-response in regions with high ionization density due to high linear-energy-transfer (LET) and ...
Lia Barbosa Valdetaro, Ellen Marie Høye, Peter Sandegaard Skyt, Jørgen Breede Baltzer Petersen, Peter Balling, Ludvig Paul Muren   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source