Results 51 to 60 of about 178,392 (266)

An interactive deep-learning workflow for head and neck gross tumour volume segmentation

Physics and Imaging in Radiation Oncology
Background and purpose: Deep learning (DL)-based auto-segmentation of head and neck cancer (HNC) gross tumour volumes remains challenging due to anatomical complexity and limited accuracy.
Zixiang Wei, Jintao Ren, Jesper Grau Eriksen, Kenneth Jensen, Hanna Rahbek Mortensen, Stine Sofia Korreman, Jasper Nijkamp   +6 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

FLASH effect tissue sparing comparison for X-ray, hadron, and VHEE irradiation modalities

Scientific Reports
FLASH-RT is an irradiation modality using Ultra-High-Dose-Rates, where a healthy tissue sparing effect is observed. Different particle types have distinct characteristics in lateral and distal dose deposition, which can affect the amount of healthy ...
Atia Ibrahimi, Stefan Both, Marc-Jan van Goethem, Francesco Romano, Alexander Gerbershagen   +4 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

The effect of editing clinical contours on deep-learning segmentation accuracy of the gross tumor volume in glioblastoma

Physics and Imaging in Radiation Oncology
Background and purpose: Deep-learning (DL) models for segmentation of the gross tumor volume (GTV) in radiotherapy are generally based on clinical delineations which suffer from inter-observer variability. The aim of this study was to compare performance
Kim M. Hochreuter, Jintao Ren, Jasper Nijkamp, Stine S. Korreman, Slávka Lukacova, Jesper F. Kallehauge, Anouk K. Trip   +6 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Clinical implementation of intensity modulated proton therapy for testicular seminoma

Acta Oncologica
Background and purpose: We have previously shown that proton therapy results in considerable reduced doses to abdominal organs at risk (OAR) which likely reduces the patient’s risk of a second malignant tumor, which is vital for this young population ...
Heidi S. Rønde, Jesper F. Kallehauge, Morten Høyer, Anne Birgitte Als, Mads Agerbæk, Jakob Lauritsen, Peter M. Petersen, Lars Dysager, Camilla J.S. Kronborg   +8 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Recent update of proton beam therapy for hepatocellular carcinoma: a systematic review and meta-analysis [PDF]

Journal of Liver Cancer
Backgrounds/Aims Although access to proton beam therapy (PBT) is limited worldwide, its use for the treatment of hepatocellular carcinoma (HCC) is gradually increasing with the expansion of new facilities.
Sun Hyun Bae, Won Il Jang, Hanna Rahbek Mortensen, Britta Weber, Mi Sook Kim, Morten Høyer   +5 more
doaj   +1 more source