Results 61 to 70 of about 3,719,428 (257)

Improving confidence in MRI-based auto-segmentation via uncertainty assessment

Acta Oncologica
Background and purpose: Accurate delineation of organs of interest (OOIs, also commonly referred to as organs at risk, OARs) is crucial for safe radiotherapy.
Jesper Folsted Kallehauge, jintao Ren, Yasmin Lassen-Ramshad   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Pamela: development of the RF system for a non-relativistic non-scaling FFAG [PDF]

, 2009
The PAMELA project(Particle Accelerator For MEdical Applications) currently consists of the design of a particle therapy facility. The project, which is in the design phase, contains Non-Scaling FFAG, particle accelerator capable of rapid beam ...
Vojnovic, B., Barlow, Roger, Pasternak, J., McIntosh, P.A., Witte, H., Aslaninejad, M., Chilton, C., Sheehy, S., Smith, S., Yokoi, T., Machida, S., Cobb, J., Tygier, S.C., Pozimski, J.K., Fenning, R, Beard, C., Gardner, I., Seviour, Rebecca, Peach, K., Kelliher, D.   +19 more
core   +1 more source

Evaluation of in vitro irradiation setup: Designed for the horizontal beamline at the Danish Centre for Particle Therapy

Acta Oncologica
Background: Radiobiological experimental setups are challenged by precise sample positioning along depth dose profile, scattering conditions, and practical difficulties that must be addressed in individual designs. The aim of this study was to produce
Anders Tobias Frederiksen, Morten Bjørn Jensen, Per Rugaard Poulsen, Niels Bassler, Brita Singers Sørensen, Mateusz Sitarz   +5 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Spot-scanning proton therapy for early breast cancer in free breathing versus deep inspiration breath-hold

Acta Oncologica
Background and purpose: Proton therapy for breast cancer is usually given in free breathing (FB). With the use of deep inspiration breath-hold (DIBH) technique, the location of the heart is displaced inferiorly, away from the internal mammary nodes and,
Line Bjerregaard Stick, Louise Lærke Nielsen, Cecilia Bui Trinh, Ihsan Bahij, Maria Fuglsang Jensen, Camilla Jensenius Skovhus Kronborg, Stine Elleberg Petersen, Linh My Hoang Thai, May-Lin Martinsen, Helle Precht, Birgitte Vrou Offersen   +10 more
doaj   +1 more source

High-Dose Proton Beam–Based Radiation Therapy in the Management of Extracranial Chondrosarcomas

, 2016
Purpose: Radiation therapy (RT) improves local tumor control in axial chondrosarcomas (CS). It is, however, often difficult to safely deliver the high doses (range, 70.2-77.4 Gy) required for achieving a high likelihood of local control, especially in ...
Lee, Richard Y., Giraud, Christine, Harmon, David, Chen, Yen-Lin E., Jacobson, Alex, Hornicek, Francis J., Choy, Edwin, DeLaney, Thomas F., Bhatt, Aashish D., Nielsen, Petur, Schwab, Joseph H.   +10 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Carbon Ion Radiotherapy for Oligo-Recurrence in the Lung

Pulmonary Medicine, 2013
The clinical results after carbon ion radiotherapy for the metastatic lung tumors believed to be in the state of oligo-recurrence were evaluated. One hundred and sixteen lesions in 91 patients with lung cancer metastasis were treated with carbon ion ...
Naoyoshi Yamamoto, Mio Nakajima, Hirohiko Tsujii, Tadashi Kamada   +3 more
doaj   +1 more source

Treatment verification in particle therapy

To make the most of the physical and biological potentials of Particle Therapy (PT), it would be extremely desirable to verify dose deposition in vivo. In this chapter, we describe and compare in vivo range verification methods currently being proposed ...
Gianoli, Chiara, De Simoni, M., Knopf, Antje   +2 more
core   +1 more source