Results 71 to 80 of about 3,719,428 (257)

Dosimetric Comparison of Plans for Photon- or Proton-Beam Based Radiosurgery of Liver Metastases

, 2016
Purpose: Radiosurgery treatment of liver metastases with photon beams has been an established method for more than a decade. One method commonly used is the stereotactic body radiation therapy (SBRT) technique.
Ana Ureba, Michael Gubanski, Siegbahn, Albert,, Lind, PA, Pehr A. Lind, Henry, Thomas,, Mondlane, G, Siegbahn, A,, Gracinda Mondlane, Thomas Henry, Gubanski, M,, Henry, T, Albert Siegbahn, Ureba, Ana,, Gubanski, Michael, Ureba, A,, Lind, Pehr A., Mondlane, Gracinda,   +17 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

FLASH effect tissue sparing comparison for X-ray, hadron, and VHEE irradiation modalities

Scientific Reports
FLASH-RT is an irradiation modality using Ultra-High-Dose-Rates, where a healthy tissue sparing effect is observed. Different particle types have distinct characteristics in lateral and distal dose deposition, which can affect the amount of healthy ...
Atia Ibrahimi, Stefan Both, Marc-Jan van Goethem, Francesco Romano, Alexander Gerbershagen   +4 more
doaj   +1 more source

An interactive deep-learning workflow for head and neck gross tumour volume segmentation

Physics and Imaging in Radiation Oncology
Background and purpose: Deep learning (DL)-based auto-segmentation of head and neck cancer (HNC) gross tumour volumes remains challenging due to anatomical complexity and limited accuracy.
Zixiang Wei, Jintao Ren, Jesper Grau Eriksen, Kenneth Jensen, Hanna Rahbek Mortensen, Stine Sofia Korreman, Jasper Nijkamp   +6 more
doaj   +1 more source

Difference in the relative biological effectiveness and DNA damage repair processes in response to proton beam therapy according to the positions of the spread out Bragg peak

Radiation Oncology, 2017
Background Cellular responses to proton beam irradiation are not yet clearly understood, especially differences in the relative biological effectiveness (RBE) of high-energy proton beams depending on the position on the Spread-Out Bragg Peak (SOBP ...
Hidehiro Hojo, Takeshi Dohmae, Kenji Hotta, Ryosuke Kohno, Atsushi Motegi, Atsushi Yagishita, Hideki Makinoshima, Katsuya Tsuchihara, Tetsuo Akimoto   +8 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Impact of beam hardening on proton stopping-power ratio estimation using photon-counting, dual-energy, and single-energy computed tomography

Physics and Imaging in Radiation Oncology
Background and purpose: Accurate stopping-power ratio (SPR) estimation is essential for treatment planning of proton therapy. However, SPR accuracy is influenced by object size and position due to beam hardening. This study compared proton SPR estimation
Lasse Bassermann, Jens Morgenthaler Edmund, Weronika Elżbieta Olech, Stine Elleberg Petersen, Maria Fuglsang Jensen, Ludvig Paul Muren, Vicki Trier Taasti   +6 more
doaj   +1 more source

Organ motion in particle therapy and the role of imaging

Organ motion is one of the main challenges to account for in particle therapy to plan and deliver an accurate treatment. In this chapter, we will explain the concept of organ motion in terms of inter- and intra-fraction variations. The current inter- and
Paganelli, C, Knopf, A, Molinelli, S, Paganelli, Chiara, Knopf, Antje, Molinelli, Silvia   +5 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

The effect of editing clinical contours on deep-learning segmentation accuracy of the gross tumor volume in glioblastoma

Physics and Imaging in Radiation Oncology
Background and purpose: Deep-learning (DL) models for segmentation of the gross tumor volume (GTV) in radiotherapy are generally based on clinical delineations which suffer from inter-observer variability. The aim of this study was to compare performance
Kim M. Hochreuter, Jintao Ren, Jasper Nijkamp, Stine S. Korreman, Slávka Lukacova, Jesper F. Kallehauge, Anouk K. Trip   +6 more
doaj   +1 more source