Results 91 to 100 of about 182,390 (296)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

3D Swin Transformer for patient-specific proton dose prediction of brain cancer patients

Acta Oncologica
Background and purpose: Accurate dose plans in proton radiotherapy with consistent target in complex anatomical regions such as the brain are crucial. This study investigates a Swin Transformer-based deep learning model for voxel-wise dose prediction in ...
Anne Haahr Andresen, Yasmin Lassen-Ramshad, Slávka Lukacova, Christian Rønn Hansen, Jesper Folsted Kallehauge   +4 more
doaj   +1 more source

PAMELA : overview and status

, 2010
The status of the PAMELA (Particle Accelerator for MEdical Applications) project to design an accelerator for proton and light ion therapy using non-scaling Fixed Field Alternating Gradient (ns-FFAG) accelerators is reviewed and ...
Easton, M.J., Tzenov, S.I., Pasternak, J., Witte, H., Johnstone, C., Edgecock, T. R., Machida, S., Cobb, J., Barlow, R. J., Fenning, R.J.L., Vojnovic, B., Owen, H. L., Pattalwar, S., Jones, B., Yokoi, T., Tygier, S.C., Gardner, I.S.K., Witte, H, Hill, M.A., Beard, Carl, Peach, K., Fenning, R., Hill, M., Khan, A., McIntosh, P.A., Bliss, N., Seviour, R., Tygier, S., Edgecock, R., Kelliher, D.J., Tzenov, S., Jones, T.J., Cobb, J H, Smith, S. L., Peach, K. J., Kelliher, D., Pattalwar, S.M., Barlow, Roger, Sheehy, S. L., Aslaninejad, M., Easton, M., Beard, C.D., Pozimski, J.K., Owen, H., Gardner, I. S K, Seviour, Rebecca, Strachan, J., McIntosh, P., Pozimski, Jürgen Klaus, Smith, S.L., Jones, T.   +50 more
core  

Particle therapy for non-small cell lung tumors: where do we stand?A systematic review of the literature

, 2014
This review article provides a systematic overview of the currently available evidence on the clinical effectiveness of particle therapy for the treatment of NSCLC and summarizes findings of in silico comparative planning studies.
Troost, Esther G C, Liyong eLin, Erik Roelofs, Simone, Charles B, Annika Jakobi, Lin, Liyong, Krista eWink, Annika eJakobi, Wink, Krista C J, Philippe eLambin, Jakobi, Annika, Roelofs, E., Lambin, Philippe, Krista C. J. Wink, Solberg, T., Troost, E.G.C., Timothy Solberg, Timothy eSolberg, Simone, C.B., Charles B. Simone, Christian Richter, Roelofs, Erik; id_orcid, Esther G. C. Troost, Roelofs, Erik, Solberg, Timothy, Wink, K.C.J., Philippe Lambin, Christian eRichter, Liyong Lin, Lambin, P., Lin, L., Jakobi, A., Richter, Christian, Richter, C., Charles B. Simone II, Esther G.C. Troost, Erik eRoelofs   +36 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Selection for proton radiotherapy of grade 1–3 glioma patients

Clinical and Translational Radiation Oncology
Background: For adult patients with grade 1–3 gliomas, identifying patients with an indication for proton therapy (PT) can be challenging due to sparse evidence supporting its benefits.
C.S. Byskov, A. Muhic, R.H. Dahlrot, C.A. Haslund, T.L. Guldberg, M. Høyer, P.W. Nyström, L. Dysager, S. Hansen, L. Haldbo-Classen, A.K. Trip, Y. Lassen-Ramshad, B. Weber, S. Lukacova, C.R. Hansen, J.F. Kallehauge   +15 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Particle-in-Particle Platform for Nanoconfinement-Induced Oncothermia

, 2018
Oncothermia, a special form of hyperthermia for oncological purposes, has been widely shown to be an effective mode of cancer therapy. However, its adoption among standard therapeutic practices has been limited by constraints in delivering sufficient ...
Ngoc Ha Hoang (4135339), Byul Hur (5987429), Kyung Taek Oh (4222858), Dongin Kim (2002045), Steve Vuong (5987426), Jong Hoon Choi (4432018), Eunsoo Yoo (5987423), Patrick Han (1272024), Jung Seok Lee (693496), Tarek Fahmy (5987432)   +9 more
core   +2 more sources