Results 101 to 110 of about 3,719,428 (257)

3D Swin Transformer for patient-specific proton dose prediction of brain cancer patients

Acta Oncologica
Background and purpose: Accurate dose plans in proton radiotherapy with consistent target in complex anatomical regions such as the brain are crucial. This study investigates a Swin Transformer-based deep learning model for voxel-wise dose prediction in ...
Anne Haahr Andresen, Yasmin Lassen-Ramshad, Slávka Lukacova, Christian Rønn Hansen, Jesper Folsted Kallehauge   +4 more
doaj   +1 more source

The effects of physical activity on pollutant particle deposition in the realistic human lung airways

, 2021
Pollutant particles emission has been a major source of worry for many years due to their negative health impacts. For health risk assessment, it is critical to understand how to assess pollutant particles transportation and deposition (TD) in human lung
Islam, Mohammad S., Zhao, Ming (R16667), Rahman, M. Mizanur (S35371), Saha, Suvash C., Dong, Kejun (R17842)   +4 more
core  

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Particle-in-Particle Platform for Nanoconfinement-Induced Oncothermia

, 2018
Oncothermia, a special form of hyperthermia for oncological purposes, has been widely shown to be an effective mode of cancer therapy. However, its adoption among standard therapeutic practices has been limited by constraints in delivering sufficient ...
Ngoc Ha Hoang (4135339), Byul Hur (5987429), Kyung Taek Oh (4222858), Dongin Kim, Ngoc Ha Hoang, Dongin Kim (2002045), Steve Vuong, Jong Hoon Choi (4432018), Kyung Taek Oh, Tarek Fahmy, Eunsoo Yoo (5987423), Patrick Han (1272024), Jung Seok Lee (693496), Jung Seok Lee, Patrick Han, Steve Vuong (5987426), Jong Hoon Choi, Eunsoo Yoo, Byul Hur, Tarek Fahmy (5987432)   +19 more
core   +2 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Selection for proton radiotherapy of grade 1–3 glioma patients

Clinical and Translational Radiation Oncology
Background: For adult patients with grade 1–3 gliomas, identifying patients with an indication for proton therapy (PT) can be challenging due to sparse evidence supporting its benefits.
C.S. Byskov, A. Muhic, R.H. Dahlrot, C.A. Haslund, T.L. Guldberg, M. Høyer, P.W. Nyström, L. Dysager, S. Hansen, L. Haldbo-Classen, A.K. Trip, Y. Lassen-Ramshad, B. Weber, S. Lukacova, C.R. Hansen, J.F. Kallehauge   +15 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Inter-fraction motion robustness in a prospective phase II trial on dose-escalated proton reirradiation for locally recurrent rectal cancer

Physics and Imaging in Radiation Oncology
Background and purpose: Intensity modulated proton therapy (IMPT) enables generation of conformal dose plans with organ at risk (OAR) sparing potential. However, pelvic IMPT robustness is challenged by inter-fraction motion caused by constant anatomical ...
C.G. Truelsen, H.S. Rønde, J.F. Kallehauge, L.Ø. Poulsen, B.M. Havelund, B.G. Pedersen, L.H. Iversen, K.G. Spindler, C.S. Kronborg   +8 more
doaj   +1 more source