Results 121 to 130 of about 182,390 (296)

Determining the effects of hyperthermia on the tumor and acute normal tissue response of FLASH radiation

Acta Oncologica
Introduction: There is limited indication of how hyperthermia would influence the unique proposition of FLASH radiation – its ability to maintain comparable tumor response while offering protection to normal tissues.
Priyanshu Manojkumar Sinha, Line Kristensen, Charlemagne Asonganyi Folefac, Lars Hjorth Præstegaard, Lone Hoffmann, Per Rugaard Poulsen, Michael Robert Horsman, Brita Singers Sørensen   +7 more
doaj   +1 more source

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Proton beam therapy in paediatric radiation oncology: Defining the limitations, uncertainties and optimisation of treatment plans

EJC Paediatric Oncology
Proton Beam Therapy (PBT) is an increasingly utilised modality for treating tumours by utilising the physical properties of accelerated proton beams. This review explores the development of PBT, its dosimetric advantages over conventional x-ray-based ...
C.S.M. Gillies, P. Lim, C. Dunlea, B. Timmermann, C. Alapetite, S. Bolle, I.F. Kristensen, K. Seiersen, Y. Lassen-Ramshad   +8 more
doaj   +1 more source

Particle therapy [PDF]

The British Journal of Radiology, 2011
openaire   +1 more source

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

Advanced Functional Materials, EarlyView.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett, Shahad K. Alsaiari, John L. Daristotle, Timothy A. Forster, Alicia Lau, Dhruv Varshney, Rania Afaneh, Andrew R. Hanna, Charles Sloane, David Mankus, Haitao Yu, Jiali Zhai, DongSoo Yun, Lisa H. Tostanoski, Abigail Lytton‐Jean, Dan H. Barouch, Charlotte E. Conn, Robert Langer, Ana Jaklenec, Calum J. Drummond   +19 more
wiley   +1 more source

Evaluation of Dosimetric Robustness of Carbon Ion Boost Therapy for Anal Carcinoma

, 2016
Purpose: The radiation therapy treatment outcome of human papillomavirus–negative anal carcinoma may be improved by the biological effectiveness of carbon ions. However, abdominal tissue motion can compromise the precision of carbon ion therapy.
Kim Melanie Kraus, Oliver Jäkel, Asja Pfaffenberger, Jürgen Debus, Florian Sterzing   +4 more
core   +1 more source

Near‐Infrared Light‐Driven Zn/Au Janus Micromotors for Multiplex SERS Detection of Anticancer Drugs

Advanced Functional Materials, EarlyView.
Zn/Au Janus micromotors, propelled by thermophoretic effects under NIR light, function as active SERS platforms for single and multiplex detection of anticancer drugs. Their dynamic motion enhances analyte exchange at the Au interface, reducing saturation and competitive adsorption, thereby improving sensitivity and extending the linear detection range.
Tijana Maric, Gohar Soufi, Ziqiao Li, Erick Chica, Amran Abdirasheed Ali Jinow, Nada Al‐Roubaï, Noor Ahmed, Yaman Göksel, Anja Boisen   +8 more
wiley   +1 more source

Spatiotemporal Drug Delivery via a Neonatal Spinal Cord ECM Hydrogel for Biomimetic Microenvironment Remodeling After Spinal Cord Injury

Advanced Functional Materials, EarlyView.
A biomimetic hydrogel derived from neonatal spinal cord ECM (DNSCM) delivers LAMB2 protein and ISP peptide to remodel the inhibitory injury microenvironment. The system sustains drug release, upregulates pro‐regenerative LAMB2, downregulates inhibitory CSPG, and promotes axonal regeneration.
Shiyu Fu, Liangchao Du, Runlin Wen, Kai Zhang, Yu Zhou, Wanrong Ma, Zhiquan Yang, Dingyang Liu, Xing Li   +8 more
wiley   +1 more source

Preclinical study of reirradiation with hyperthermia in recurrent murine tumors and normal mouse skin

Acta Oncologica
Background: Re-irradiation is an essential treatment option for recurrent tumours but is limited by normal tissue tolerance. Hyperthermia can enhance radiation efficacy by impairing DNA repair and improving tumor oxygenation; however, limited preclinical
Charlemagne A Folefac, Priyanshu M. Sinha, Niels Bassler, Brita S. Sørensen, Michael R. Horsman   +4 more
doaj   +1 more source

Development of an IH-DTL injector for the Heidelberg cancer therapy project

, 2005
Cancer has become one of the most fatal diseases. The Heidelberg Heavy Ion Cancer Therapy (HICAT) has the potential to become an important and efficient treatment method because of its excellent “Bragg peak” characteristics and on-line irradiation ...
Lu, Yuanrong
core