Results 141 to 150 of about 182,390 (296)

Understanding the Physics of Particle Accelerators

This open access book introduces readers to the physics of particle accelerators, by means of beam dynamics simulations and exercises using the computer code ZGOUBI.
Méot, François
core   +1 more source

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

Particle therapy

, 1993
Particle therapy has a long history. The experimentation with particles for their therapeutic application got started soon after they were produced in the laboratory.
Raju, M. R.
core  

Co‐Electrospinning Extracellular Matrix with Polycaprolactone Enables a Modular Approach to Balance Bioactivity and Mechanics of a Multifunctional Bone Wrap

Advanced Healthcare Materials, EarlyView.
The incorporation of nondigested ECM and synthetic polymers into a co‐electrospinning system enables the decoupling of bioactivity and mechanical properties within a single wrap. This technique is used to develop a multifunctional bone wrap that achieves augmented membrane durability, sustained infection control, and enhanced vascularity for use in ...
Sarah Jones, Madeline Laude, Zeenat Oyebanji, Ruchi Birur, Andres Luengo Martinez, Isabelle Gilbert, Phillip Baek, Nichole Longbottom, Nicole McCullough, Staci J. Horn, Chien‐Yu Lin, Matthew J. Lohr, Fred Clubb, Manuel K. Rausch, Elizabeth Cosgriff‐Hernandez   +14 more
wiley   +1 more source

Cystic Fibrosis gene therapy: methods for the optimisation of CFTR gene delivery.

, 2010
Gene therapy potentially holds the key for the treatment and cure of many genetic diseases, including cystic fibrosis. A number of delivery methods have been developed for the integration of a functional gene into the host genome, one of which is the use
Kremer, Karlea Lee
core  

Functional Precision Oncology Approach Using Nanoliter Droplet Array for Drug Sensitivity Testing in Lung Cancer

Advanced Healthcare Materials, EarlyView.
A miniaturized drug sensitivity and resistance testing (DSRT) workflow based on the Droplet Microarray (DMA) platform enables functional drug testing using minimal patient‐derived tumor material. By screening nanoliter‐scale droplets containing as few as 300 cells, this approach generates reproducible and tumor‐specific drug response profiles ...
Maryam Salarian, Vicky L. Schiling, Thomas Muley, Michael Allgäuer, Florian Eichhorn, Michael Meister, Marc A. Schneider, Anna A. Popova   +7 more
wiley   +1 more source

PARTICLE THERAPY DELIVERY SYSTEM

, 2017
A particle therapy delivery system (10) comprising a support structure (12) defining at least a partial enclosure within which a patient is positioned in use, and a particle delivery line for delivering particles to a patient, wherein the support ...
Burt, Graeme, Apsimon, Robert, Owen, Hywel   +2 more
core   +1 more source

Corrigendum to “Proton dose calculation on cone-beam computed tomography using unsupervised 3D deep learning networks”. [Phys Imaging Radiat Oncol 2024;32:100658]

Physics and Imaging in Radiation Oncology
Casper Dueholm Vestergaard, Ulrik Vindelev Elstrøm, Ludvig Paul Muren, Jintao Ren, Ole Nørrevang, Kenneth Jensen, Vicki Trier Taasti   +6 more
doaj   +1 more source

Modular Control of PEG‐Poly(2‐Oxazoline) Co‐Assembly Enables Tunable Aggregate Properties for Intraocular Pressure Management

Advanced Healthcare Materials, EarlyView.
A thermo‐responsive poly(2‐oxazoline)‐based injectable formulation is developed to modulate intraocular pressure (IOP) in both normal and hypotonic eyes. By adjusting the PEG content, the aggregation behavior is finely tuned, enabling IOP elevation without long‐term deposition.
Yuji Tanaka, Shohei Morikawa, Shigehito Osawa   +2 more
wiley   +1 more source

Editorial: Image-guided particle therapy. [PDF]

Front Oncol, 2023
Li H, Durante M, Jäkel O, Kong L, Lu L.
europepmc   +1 more source