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Particle therapy in Europe [PDF]
Molecular Oncology, 2020 Particle therapy using protons or heavier ions is currently the most advanced form of radiotherapy and offers new opportunities for improving cancer care and research. Ions deposit the dose with a sharp maximum – the Bragg peak – and normal tissue receives a much lower dose than what is delivered by X‐ray therapy.Grau, Cai, Durante, Marco, Georg, Dietmar, Langendijk, Johannes A., Weber, Damien C. +4 morecore +11 more sourcesParticle Therapy for Breast Cancer [PDF]
Cancers, 2022 Particle therapy has received increasing attention in the treatment of breast cancer due to its unique physical properties that may enhance patient quality of life and reduce the late effects of therapy. In this review, we will examine the rationale for the use of proton and carbon therapy in the treatment of breast cancer and highlight their potential Roman O. Kowalchuk, Kimberly S. Corbin, Rachel B. Jimenez +2 moreopenaire +3 more sourcesParticle Therapy
, 2022 Particle therapy is a form of radiation therapy in which high energy ionised particles, most commonly protons or neutrons, are aimed at the target tissue. In the context of breast cancer treatment, proton beam therapy is the most commonly used particle therapy and is therefore the focus of this section.Kirby, Anna M., Boersma, Liesbeth J.openaire +2 more sourcesParticle therapy for noncancer diseases [PDF]
Medical Physics, 2012 Radiation therapy using high‐energy charged particles is generally acknowledged as a powerful new technique in cancer treatment. However, particle therapy in oncology is still controversial, specifically because it is unclear whether the putative clinical advantages justify the high additional costs.C. Bert, R. Engenhart Cabillic, DURANTE, MARCO +2 moreopenaire +4 more sourcesParticle therapy in the future of precision therapy [PDF]
The British Journal of Radiology, 2020 The first hospital-based treatment facilities for particle therapy started operation about thirty years ago. Since then, the clinical experience with protons and carbon ions has grown continuously and more than 200,000 patients have been treated to date.Lukas, Schaub, Semi Ben, Harrabi, Juergen, Debus +2 moreopenaire +2 more sourcesDoes uncertainty in variability in relative biological effectiveness affect patient treatment in proton therapy? [PDF]
, 2021 Clinical treatment with protons uses the concept of relative biological effectiveness (RBE) to convert the absorbed dose into an RBE-weighted dose that equals the dose for radiotherapy with photons causing the same biological effect. Currently, in proton Whitfield, Gillian A, Bauer, Julia, Pawelke, Jörg, Whitfield, Gillian A., Krause, Mechthild, Lühr, Armin, Karger, Christian, Sørensen, Brita S., Dasu, Alexandru,, Schwarz, Marco, Wagenaar, Dirk; id_orcid, Underwood, Tracy, Burnet, Neil G, Karger, Christian P, Underwood, Tracy S A, Dasu, Alexandru, Høyer, Morten, Wagenaar, Dirk, Burnet, Neil, Sørensen, Brita S, Høyer, M., Sørensen, B. S., Karger, C. P., Dasu, A., Pawelke, J., Bauer, J., Schwarz, M., Krause, M., Lühr, A., Wagenaar, D., Armin Lühr, Morten Høyer, Marco Schwarz, Christian P. Karger, Alexandru Dasu, Dirk Wagenaar, Brita S. Sørensen, Julia Bauer, Tracy S.A. Underwood, Neil G. Burnet, Jörg Pawelke, Gillian A. Whitfield, Mechthild Krause +42 morecore +1 more sourceMolecular Signaling in Response to Charged Particle Exposures and its Importance in Particle Therapy [PDF]
, 2018 Energetic, charged particles elicit an orchestrated DNA damage response (DDR)
during their traversal through healthy tissues and tumors. Complex DNA damage
formation, after exposure to high linear energy transfer (LET) charged particles, results
in ...Hellweg, Christine E., Chishti, Arif Ali, Diegeler, Sebastian, Baumstark-Khan, Christa, Henschenmacher, Bernd, Spitta, Luis F. +5 morecore +1 more sourceRadiation dose constraints for organs at risk in neuro-oncology; the European Particle Therapy Network consensus [PDF]
, 2018 Purpose: For unbiased comparison of different radiation modalities and techniques, consensus on delineation of radiation sensitive organs at risk (OARs) and on their dose constraints is warranted.Burnet, Neil G., Whitfield, Gillian A., Piero Fossati, Langendijk, Johannes A., Beate Timmermann, Burnet, Neil G. (author), Wiggenraad, R., Coremans, Ida E.M., Lambrecht M, de Ruysscher D, Ida E.M. Coremans, Nystrom, PW, Langendijk JA, Langendijk, J, Perpar, Ana, Vitek, Pavel, Roelofs, Erik (author), Renard L, Troost, Esther G. C., Coremans, IEM, Høyer, Morten (author), Lambrecht, M., Langendijk, JA, Fossati, Piero (author), Ana Perpar, Perpar, A, Fossati, P, Méndez Romero A, Vitek, Pavel (author), Calugaru, V, Langendijk, J.A., Høyer M, Lambrecht, Maarten, Alapetite, Claire (author), De Ruysscher, D, Burnet, NG, Burnet, N, Romero, A, Whitfield, Gillian A. (author), Paulsen, F, Eekers, Daniëlle B.P. (author), Gillian A. Whitfield, Esther G.C. Troost, Timmermann B, van der Weide, HL, Erik Roelofs, Weber DC, Langendijk, Johannes A. (author), Frank Paulsen, Coremans, I.E.M., Nystrom, P.W., Paulsen, Frank (author), Timmermann, B, Perpar, Ana (author), Eekers, Danielle B. P., Renard, Laurette (author), Eekers, D.B.P., Fossati P, Vitek, P, Roelofs, E., Méndez Romero, Alejandra (author), Weber, Damien C. (author), Ruud Wiggenraad, Alapetite, C., Whitfield, Gillian A, Troost, Esther G.C. (author), Pavel Vitek, Ruysscher, D, Eekers DBP, Nyström, P, Alejandra Méndez Romero, Mendez Romero, Alejandra, Paulsen, F., Calugaru, Valentin (author), Maarten Lambrecht, Wiggenraad R, Coremans, I, Renard, L., Timmermann, Beate, Lambrecht, Maarten (author), Calugaru V, Romero, Alejandra Mendez, de Ruysscher, Dirk, Laurette Renard, Dirk de Ruysscher, Roelofs, E, Valentin Calugaru, Troost, EGC, de Ruysscher, Dirk (author), Romero, A.M., Weide, H.L. van der, van der Weide HL, Nyström PW, Troost, E, Morten Høyer, Taskforce European Particle, Weber, D, Whitfield GA, Paulsen, Frank, Troost EGC, Coremans, Ida E. M., Troost, E.G.C., Weber, Damien C., Nystrom, Petra Witt, Hoyer, Morten, Troost, Esther G.C., Roelofs, Erik; id_orcid, Roelofs, Erik, Roelofs E, Paulsen F, Whitfield, G.A., Burnet, N.G., van der Weide, Hiske L. (author), Alapetite C, Wiggenraad, Ruud, Renard, Laurette, Burnet NG, Perpar A, Neil G. Burnet, Timmermann, B., Coremans IEM, Weber, DC, Hoyer, M., van der Weide, Hiske L., Vitek P, van der Weide, H, Vitek, P., Coremans, Ida E.M. (author), Renard, L, Eekers, D, Hiske L. van der Weide, Ruysscher, D. de, Wiggenraad, Ruud (author), Perpar, A., Eekers, Danielle B.P., Timmermann, Beate (author), Johannes A. Langendijk, Claire Alapetite, Alapetite, C, Fossati, Piero, Daniëlle B.P. Eekers, Witt Nyström, Petra (author), Alapetite, Claire, Eekers, DBP, Fossati, P., Lambrecht, M, Whitfield, GA, Weber, D.C., Wiggenraad, R, Calugaru, Valentin, Damien C. Weber, Petra Witt Nyström, Calugaru, V., Hoyer, M, Høyer, M +154 morecore +1 more sourceConceptual design of a nonscaling fixed field alternating gradient accelerator
for protons and carbon ions for charged particle therapy [PDF]
, 2013 The conceptual design for a nonscaling fixed field alternating gradient accelerator suitable for charged particle therapy (the use of protons and other light ions to treat some forms of cancer) is ...Wilson P, J. Strachan, J. H. Cobb, P. A. McIntosh, Edgecock TR, Witte, H., Cobb, JH, Tygier S, Edgecock, T. R., Rochford J, P. Wilson, Easton, MJ, Sheehy, SL, Owen HL, Smith, SL, J. Rochford, Machida, S., Wilson, P., Strachan, J, Prior, C.R., Vojnovic, B, Witte H, R. Fenning, Owen, H.L., Barlow, R. J., Vojnovic, B., J. Pasternak, R. Seviour, Pattalwar, S., S. Tygier, Barlow RJ, Jones, B., Machida, S, Cobb JH, Yokoi, T., Beard, CD, Edgecock, TR, Gardner, I.S.K., N. Bliss, Pattalwar, S, Kelliher, DJ, C. D. Beard, I. S. K. Gardner, Fenning, R., Fenning R, B. Vojnovic, McIntosh, P.A., Strachan J, T. R. Edgecock, A. Khan, Seviour, R., Jones B, Cobb, J. H., Aslaninejad M, Prior, CR, Owen, HL, Hill, M. A., Smith, S. L., Pozimski J, Peach, K.J., Peach, K. J., Seviour R, M. J. Easton, Rochford, J, Seviour, R, Easton, M. J., Beard, C. D., Gardner, I. S. K., Prior, C. R., B. Jones, Beard, C.D., Seviour, Rebecca, Strachan, J., Gardner ISK, Smith SL, Cobb, J.H., Jones, T., Easton, M.J., Aslaninejad, M, Pasternak, J., S. L. Sheehy, Jones, T, C. R. Prior, Kelliher, D. J., D. J. Kelliher, Wilson, P, Yokoi, T, Yokoi T, McIntosh PA, Rogers CT, Rogers, C.T., M. A. Hill, S. L. Smith, Pasternak, J, Vojnovic, Boris, Hill MA, S. Machida, Pozimski, J, Johnstone, CJ, Owen, H. L., R. J. Barlow, Gardner, ISK, C. J. Johnstone, Beard CD, H. L. Owen, H. Witte, Gardner, I. S.K., Jones, B, Hill, M.A., Witte, H, J. Pozimski, Rochford, J., Machida S, Jones T, T. Yokoi, Khan, A., Prior CR, Pattalwar S, Bliss, N., Johnstone CJ, Tygier, S., McIntosh, PA, Rogers, C. T., Edgecock, R., Kelliher, D.J., Peach KJ, Pozimski, J., Khan, A, Barlow, R.J., M. Aslaninejad, Johnstone, C.J., Sheehy SL, Vojnovic B, C. T. Rogers, Tygier, S, Johnstone, C. J., McIntosh, P. A., Kelliher DJ, Barlow, RJ, S. Pattalwar, Sheehy, S. L., Pasternak J, Aslaninejad, M., Bliss N, Khan A, Easton MJ, T. Jones, Rogers, CT, K. J. Peach, Fenning, R, Gardner, I. S K, Hill, MA, Smith, S.L., Bliss, N +153 morecore +1 more sourceProton Beam Therapy for Children With Neuroblastoma: Experiences From the Prospective KiProReg Registry
Frontiers in Oncology, 2021 ObjectiveRadiotherapy (RT) is an integral part of the interdisciplinary treatment of patients with high-risk neuroblastoma (NB). With the continuous improvements of outcome, the interest in local treatment strategies that reduce treatment-related side ...Danny Jazmati, Sarina Butzer, Barbara Hero, Dalia Ahmad Khalil, Julien Merta, Christian Bäumer, Christian Bäumer, Christian Bäumer, Gina Plum, Jörg Fuchs, Friederike Koerber, Theresa Steinmeier, Sarah Peters, Jerome Doyen, Theresa Thole, Matthias Schmidt, Christoph Blase, Stephan Tippelt, Angelika Eggert, Rudolf Schwarz, Thorsten Simon, Beate Timmermann, Beate Timmermann +22 moredoaj +1 more source