Results 61 to 70 of about 647,012 (294)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Particle Filters: A Hands-On Tutorial
Sensors, 2021 The particle filter was popularized in the early 1990s and has been used for solving estimation problems ever since. The standard algorithm can be understood and implemented with limited effort due to the widespread availability of tutorial material and ...
Jos Elfring +2 more
doaj +1 more source
Multi-Target Tracking in Distributed Sensor Networks using Particle PHD Filters
, 2018 Multi-target tracking is an important problem in civilian and military applications. This paper investigates multi-target tracking in distributed sensor networks.
Leonard, Mark R., Zoubir, Abdelhak M.
core +1 more source
Assimilating SAR-derived water level data into a hydraulic model: a case study [PDF]
, 2011 Satellite-based active microwave sensors not only provide synoptic overviews of flooded areas, but also offer an effective way to estimate spatially distributed river water levels.
De Keyser, Robain +10 more
core +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Legal Statutes of Arab Refugees [PDF]
, 1968 The recently developed particle filter offers a general numerical tool to approximate the state a posteriori density in nonlinear and non-Gaussian filtering problems with arbitrary accuracy.
Gustafsson, Fredrik +2 more
core +1 more source
Nudging the particle filter [PDF]
, 2019 We investigate a new sampling scheme aimed at improving the performance of particle filters whenever (a) there is a significant mismatch between the assumed model dynamics and the actual system, or (b) the posterior probability tends to concentrate in ...
Akyıldız, Ömer Deniz +1 more
core +2 more sources
Split-Gaussian particle filter [PDF]
2015 23rd European Signal Processing Conference (EUSIPCO), 2015 Publication in the conference proceedings of EUSIPCO, Nice, France ...
Kokkala, Juho, Särkkä, Simo
openaire +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
PARTICLE FILTER BASED VEHICLE TRACKING APPROACH WITH IMPROVED RESAMPLING STAGE [PDF]
ICTACT Journal on Image and Video Processing, 2014 Optical sensors based vehicle tracking can be widely implemented in traffic surveillance and flow control. The vast development of video surveillance infrastructure in recent years has drawn the current research focus towards vehicle tracking using high ...
Wei Leong Khong +4 more
doaj