Results 61 to 70 of about 61,960 (301)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
On coupling particle filter trajectories [PDF]
Statistics and Computing, 2017 Particle filters are a powerful and flexible tool for performing inference on state-space models. They involve a collection of samples evolving over time through a combination of sampling and re-sampling steps. The re-sampling step is necessary to ensure that weight degeneracy is avoided.
Deborshee Sen +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Split-Gaussian particle filter [PDF]
2015 23rd European Signal Processing Conference (EUSIPCO), 2015 Publication in the conference proceedings of EUSIPCO, Nice, France ...
Juho Kokkala, Simo Särkkä
openaire +1 more source
A particle filter for freeway traffic estimation [PDF]
, 2004 This paper considers the traffic flow estimation problem for the purposes of on-line traffic prediction, mode detection and ramp-metering control. The solution to the estimation problem is given within the Bayesian recursive framework. A particle filter (
Mihaylova, Lyudmila +7 more
core +1 more source
LubricantsThis paper proposes a dynamic-projection-integrated particle-filtering-based identification strategy for the friction characteristic curve of a train wheelset under the slipping fault condition.
Shicai Yin +5 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Time-Varying DOA Tracking Algorithm Based on Generalized Labeled Multi-Bernoulli
IEEE Access, 2021 Direction of arrival (DOA) tracking for multi-sources is a hot issue in array signal processing. To deal with the problem that sources DOA and their number are time-varying, a DOA tracking algorithm based on Generalized Labeled Multi-Bernoulli (GLMB ...
Jun Zhao +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
IEEE Transactions on Signal ProcessingIn cognitive systems, recent emphasis has been placed on studying the cognitive processes of the subject whose behavior was the primary focus of the system's cognitive response. This approach, known as inverse cognition, arises in counter-adversarial applications and has motivated the development of inverse Bayesian filters.
Himali Singh +2 more
openaire +2 more sources