Results 41 to 50 of about 4,195,211 (256)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Experimental study on application of foam fluids in restraining seepage failure of soils
Yantu gongcheng xuebaoEmbankment project is an important part of the disaster prevention and reduction system of China. Seepage failure, such as piping is a serious challenge to the safety of the embankment project.
WANG Yuan 1, GONG Jiakun 2, QIU Haotian 2, QI Tian 2
doaj +1 more source
Recent progress of particle migration in viscoelastic fluids.
Lab on a Chip, 2018 Recently, research on particle migration in non-Newtonian viscoelastic fluids has gained considerable attention. In a viscoelastic fluid, three dimensional (3D) particle focusing can be easily realized in simple channels without the need for any external
Dan Yuan +6 more
semanticscholar +1 more source
, 2020 A large number of statistics indicate that broken rock mass always transforms into a flowing channel and leads to water inrush disasters in mining engineering, such as fault, karst, and strongly weathered rock mass.
Wenhao Shi, Tianhong Yang
semanticscholar +1 more source
Aerosol and Air Quality Research, 2020 Electrostatic precipitation processes have been widely applied to remove particulate matter from flue gases in coal-fired power stations. A high negative voltage is usually applied to a discharge electrode so that the gases are ionized in such processes.
W. Gao +7 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Frontiers in Earth ScienceWith shallow mineral resources gradually exhausted, deep mineral resource development is critical for national resource security yet faces severe challenges when tunnels cross weakly consolidated rock masses like faults and collapse columns.
Peihong Xin +13 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Migration characteristics of zinc oxide nanoparticles in food contact material polyvinyl chloride
Zhongguo shipin weisheng zazhi, 2021 ObjectiveTo investigate the zinc oxide nanoparticles (ZnO-Np) migration characteristics in the food contact material, namely polyvinyl chloride (PVC).MethodsIn this study, PVC/ZnO-Np composite with 1% w/w of ZnO-Np was prepared.
MIAO Hongjian, LING Yun, ZHAO Yunfeng
doaj +1 more source