Results 31 to 40 of about 21,937 (246)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A radiative neutrino mass model with semi-annihilating boosted dark matter

Journal of High Energy Physics
Boosted dark matter can provide a distinctive signature of a non-minimal dark sector. In this work, we construct a radiative neutrino mass model that allows for the production of boosted dark matter in the present universe through semi-annihilation.
Motoko Fujiwara, Takashi Toma
doaj   +1 more source

Multilepton signatures from dark matter at the LHC

Journal of High Energy Physics, 2022
Leptonic signatures of Dark Matter (DM) are one of the cleanest ways to discover such a secluded form of matter at high energy colliders. We explore the full parameter space relevant to multi-lepton (2- and 3-lepton) signatures at the Large Hadron ...
Alexander Belyaev, Ulla Blumenschein, Arran Freegard, Stefano Moretti, Dipan Sengupta   +4 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Perturbative unitarity violation in radiative capture transitions to dark matter bound states

Journal of High Energy Physics
We investigate the formation of bound states of non-relativistic dark matter particles subject to long-range interactions through radiative capture.
Martin Beneke, Tobias Binder, Lorenzo De Ros, Mathias Garny, Stefan Lederer   +4 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Electrochemical Behavior of Flame‐Sprayed Sc‐Doped AlCoCrFeMo High‐Entropy Alloy Coatings in 3.5% Sodium Chloride Solution

Advanced Engineering Materials, EarlyView.
Scandium (Sc)‐doped AlCoCrFeMo HEA coatings are fabricated via flame spraying with 0.1, 0.3, and 0.5 wt% Sc additions. Among these, the HEA‐Sc0.3 coating exhibits the highest corrosion resistance, indicated by a more positive corrosion potential and lower current density.
Pankaj Kumar, Akash Vyas, Mohammad Aatif Qazi, Nashit Jalal, Maria Ophelia Jarligo, Mostafa Yakout, Jing Liu, André McDonald   +7 more
wiley   +1 more source

Revisiting the decoupling limit of the Georgi-Machacek model with a scalar singlet

Journal of High Energy Physics
We study the connection between collider and dark matter phenomenology in the singlet extension of the Georgi-Machacek model. In this framework, the singlet scalar serves as a suitable thermal dark matter (DM) candidate. Our focus lies on the region v χ <
Geneviève Bélanger, Juhi Dutta, Rohini M. Godbole, Sabine Kraml, Manimala Mitra, Rojalin Padhan, Abhishek Roy   +6 more
doaj   +1 more source

Probing the Fundamental Nature of Particle Dark Matter

Understanding the fundamental nature of dark matter (DM) is one of the most significant scientific challenges of our time. A compelling hypothesis is that DM consists of a new, yet-to-be-discovered particle. Among the leading candidates are weakly interacting massive particles (WIMPs) and axion-like particles (ALPs), both of which can be investigated ...
Regis, Marco, Basu, Aritra, Beck, Geoff, Bernardi, Gianni, Marchegiani, Paolo, Schwarz, Dominik J., Taoso, Marco, Todarello, Elisa, Tolley, Emma, Uhlemann, Cora   +9 more
openaire   +2 more sources

Influence of Scan Strategies in Electron Beam Powder Bed Fusion on Solidification, Microstructure, and High‐Temperature Compressive Properties of γ′‐Strengthened Inconel 738LC

Advanced Engineering Materials, EarlyView.
Experiments and thermophysical simulations were conducted to investigate the electron beam powder bed fusion electron beam (PBF‐EB/M) process for the γ′‐strengthened nickel‐based superalloy Inconel 738LC. The results demonstrate the impact of process‐induced microstructural variations on high‐temperature mechanical behavior, providing a basis for ...
Jan Niklas Petenati, Karthik Kumar Banku, Prasanth Bondi, Ivan Zhirnov, Yangyiwei Yang, Gordon Schmidt, Jürgen Christen, Georg Hasemann, Manja Krüger, Bai‐Xiang Xu, Bilal Gökce, Silja‐Katharina Rittinghaus   +11 more
wiley   +1 more source