Results 111 to 120 of about 862,515 (311)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Voltammetric Sizing of Inert Particles

ChemPhysChem, 2005
AbstractThe average size of inert particles is determined using a simple electrochemical procedure. Alumina particles are deposited on an edge‐plane graphite electrode, and a cyclic voltammogram is recorded. The scan rate employed varies between 0.2 and 2 V s−1.
Davies, T, Lowe, E, Wilkins, S, Compton, R   +3 more
openaire   +3 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Explaining global surface aerosol number concentrations in terms of primary emissions and particle formation [PDF]

, 2010
We synthesised observations of total particle number (CN) concentration from 36 sites around the world. We found that annual mean CN concentrations are typically 300–2000 cm -3 in the marine boundary layer and free troposphere (FT) and 1000–10 000 cm -3 ...
Mihalopoulos, Nikos, Wiedensohler, Alfred, Andrews, Elisabeth, J. Gras, A. Hamed, Mann, G.W., K. Sellegri, Baltensperger, Urs, Kivekäs, Niku, M. Komppula, A. Laaksonen, Mihalopoulos, Ninolaos, J. Merikanto, A. Wiedensohler, Sun, Junying, Harrison, Roy M., Mihalopoulos, N., Boy, M., Jennings, S. Gerard, Birmili, Wolfram, A. Minikin, P. Laj, Merikanto, J., Ogren, J. A., Ogren, John A., Laakso, Lauri, Weller, Rolf, S. G. Jennings, Reddington, C.L., Pickering, S., R. M. Harrison, Mann, G. W., Kulmala, Markku, Minikin, Andreas, Boy, Michael, Laaksonen, A., M. Kulmala, N. Kivekäs, O'Dowd, C., U. Baltensperger, Carslaw, K.S., L. Laakso, Ogren, J.A., Carslaw, K. S., R. Talbot, Spracklen, D.V., Reddington, Carly L., Talbot, R., K. S. Carslaw, M. Boy, Harrison, R. M.; id_orcid, Andrews, E., W. Birmili, Sellegri, Karine, Lihavainen, Heikki, Gras, J., Krejci, Radovan,, O'Dowd, Colin D., Spracklen, D. V., Sun, Youbin, Baltensperger, U., Krejci, Radek, O'Dowd, Collin D., Komppula, M., Sellegri, K., Talbot, Robert, Kouvarakis, Giorgos, Laj, P., G. W. Mann, Jennings, S.G., Hamed, A., Weingartner, E., Krejci, R., Carslaw, Kenneth S., Lihavainen, H., Wiedensohler, A., Harrison, R. M., Sun, J., Birmili, W., Mann, Graham W., Bonn, B., Kivekäs, N., Komppula, Mika, Spracklen, Dominick V., Merikanto, Joonas, Laj, Paolo, Hamed, Amar, Jennings, S. G., E. Weingartner, Weingartner, Ernest, Laakso, L., J. A. Ogren, Minikin, A., R. Krejci, Gras, John, S. Pickering, Reddington, C. L., Harrison, R.M., Jennings, Stephen G., Pickering, Steven, H. Lihavainen, B. Bonn, C. O'Dowd, Weller, R., Kulmala, M., N. Mihalopoulos, J. Sun, G. Kouvarakis, Kouvarakis, G., E. Andrews, D. V. Spracklen, Bonn, Boris, Lihavainen, H.Finnish Meteorol. Inst.,, Laaksonen, Ari, C. L. Reddington, Krejci, Radovan, Harrison, Roy Michael, R. Weller   +117 more
core   +1 more source

Particle size distribution of dried sewage sludge

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2012
The aim of this paper was to determine the basic granulometric curves related to the dried sewage sludge and particles size distribution according to Rosin-Rammler, which belongs to the most widely used methods for the statistical distribution of ...
Radovan Kukla, Petr Junga, Jana Ševčíková   +2 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

99mTc-SnF2 colloid “LLK”: particle size, morphology, and leukocyte labelling behaviour [PDF]

, 2003
99mTc-SnF2 colloid (Radpharm LLK) leucocyte labelling agent is used in whole blood, exploiting phagocytosis. The objectives of this work were to optimize leucocyte labelling in leucocyte-enriched plasma, and to investigate: (i) the effect of temperature ...
Carter, N., O'Doherty, T., Onuegbulem, E., Pooley, F., Leahy, M., McClelland, C., Blower, P., O'Doherty, M., Newsam, R., Ensing, G.   +9 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Continuum modelling of granular particle flow with inelastic inter-particle collisions [PDF]

, 2003
The kinetic theory of granular flow is a successful model for gas-solid flows. However, inelastic collisions between particles, among other mechanisms, cause agglomeration of particles, which may be the reason why undue sensitivity of the model to any ...
Zhang, Y.H., Reese, J.M.
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source