Results 91 to 100 of about 2,155,826 (293)

Particle size distribution of dried sewage sludge

open access: yesActa Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2012
The aim of this paper was to determine the basic granulometric curves related to the dried sewage sludge and particles size distribution according to Rosin-Rammler, which belongs to the most widely used methods for the statistical distribution of ...
Radovan Kukla   +2 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Influence of Particle Size Distribution on Random Close Packing

open access: yes, 2013
The densest amorphous packing of rigid particles is known as random close packing. It has long been appreciated that higher densities are achieved by using collections of particles with a variety of sizes.
Desmond, Kenneth W., Weeks, Eric R.
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Modeling radiation in particle clouds: On the importance of inter-particle radiation for pulverized solid fuel combustion

open access: yes, 2014
The importance of inter-particle radiation for clusters of gray and diffuse particles is investigated. The radiative cooling of each individual particle is found to vary strongly with its position in the cluster, and a mean radiative particle cooling ...
Haugen, Nils Erland L.   +1 more
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Influence of particle size in silo discharge

open access: yesEPJ Web of Conferences, 2017
Recently Janda et al. [Phys. Rev. Lett. 108, 248001 (2012)] reported an experimental study where it was measured the velocity and volume fraction fields of 1 mm diameter stainless steel beads in the exit of a two-dimensional silo.
Gella Diego, Maza Diego, Zuriguel Iker
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

open access: yesAging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang   +3 more
wiley   +1 more source

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