Results 71 to 80 of about 2,155,826 (293)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Moment Dynamics of Zirconia Particle Formation for Optimizing Particle Size Distribution

open access: yesNanomaterials, 2019
We study the particle formation process of Zirconia ( ZrO 2 )-based material. With a model-based description of the particle formation process we aim for identifying the main growth mechanisms for different process parameters.
Wolfgang Halter   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Boson star with particle size effects

open access: yes, 2017
A simple model to study boson stars is to consider these stellar objects as quantum systems of $N$ identical self-gravitating particles within a non-relativistic framework.
Semay, C.
core  

Towards a complete inventory of stratospheric dust particles, with implications for their classification [PDF]

open access: yes, 1984
Several investigators have recently proposed classification schemes for stratospheric dust particles [1-3]. In addition, extraterrestrial materials within stratospheric dust collections may be used as a measure of micrometeorite flux [4]. However, little
Mackinnon, Ian D.R.   +2 more
core   +1 more source

Computational analysis of shock-induced flow through stationary particle clouds

open access: yes, 2019
We investigate the shock-induced flow through random particle arrays using particle-resolved Large Eddy Simulations for different incident shock wave Mach numbers, particle volume fractions and particle sizes.
Omang, Marianne Gjestvold   +3 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

SUCELL Test Conditions Optimization of HELOS/BF Laser Particle Size Analyzer

open access: yesYankuang ceshi, 2013
The Laser Particle Size Analyzer is being more widely used due to its fast test speed, convenient operation and good repeatability, to name a few of its qualities.
LU Xin-cheng, CAO Jing-yang
doaj  

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