Results 61 to 70 of about 813,177 (264)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

The Particle Size of Rubella Virus

Journal of General Virology, 1967
Summary The sedimentation coefficient of rubella virus was found to be 342 S and the buoyant density of 1.085 g./cm.3. The calculated particle diameter, 850 A, was in good agreement with that found by ultrafiltration, namely 900 A.
B, Russell, G, Selzer, H, Goetze
openaire   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Exploring the enzymatic landscape: distribution and kinetics of hydrolytic enzymes in soil particle-size fractions

, 2005
The location of extracellular enzymes within the soil architecture and their association with the various soil components affects their catalytic potential.
Kandeler, E., Wermbter, N., Jarvis, S. C., Wood, M., Marx, M. C.   +4 more
core   +1 more source

Voltammetric Sizing of Inert Particles

ChemPhysChem, 2005
AbstractThe average size of inert particles is determined using a simple electrochemical procedure. Alumina particles are deposited on an edge‐plane graphite electrode, and a cyclic voltammogram is recorded. The scan rate employed varies between 0.2 and 2 V s−1.
Davies, T, Lowe, E, Wilkins, S, Compton, R   +3 more
openaire   +3 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Explaining global surface aerosol number concentrations in terms of primary emissions and particle formation [PDF]

, 2010
We synthesised observations of total particle number (CN) concentration from 36 sites around the world. We found that annual mean CN concentrations are typically 300–2000 cm -3 in the marine boundary layer and free troposphere (FT) and 1000–10 000 cm -3 ...
Mihalopoulos, Nikos, Wiedensohler, Alfred, Andrews, Elisabeth, J. Gras, A. Hamed, Mann, G.W., K. Sellegri, Baltensperger, Urs, Kivekäs, Niku, M. Komppula, A. Laaksonen, Mihalopoulos, Ninolaos, J. Merikanto, A. Wiedensohler, Sun, Junying, Harrison, Roy M., Mihalopoulos, N., Boy, M., Jennings, S. Gerard, Birmili, Wolfram, A. Minikin, P. Laj, Merikanto, J., Ogren, J. A., Ogren, John A., Laakso, Lauri, Weller, Rolf, S. G. Jennings, Reddington, C.L., Pickering, S., R. M. Harrison, Mann, G. W., Kulmala, Markku, Minikin, Andreas, Boy, Michael, Laaksonen, A., M. Kulmala, N. Kivekäs, O'Dowd, C., U. Baltensperger, Carslaw, K.S., L. Laakso, Ogren, J.A., Carslaw, K. S., R. Talbot, Spracklen, D.V., Reddington, Carly L., Talbot, R., K. S. Carslaw, M. Boy, Harrison, R. M.; id_orcid, Andrews, E., W. Birmili, Sellegri, Karine, Lihavainen, Heikki, Gras, J., Krejci, Radovan,, O'Dowd, Colin D., Spracklen, D. V., Sun, Youbin, Baltensperger, U., Krejci, Radek, O'Dowd, Collin D., Komppula, M., Sellegri, K., Talbot, Robert, Kouvarakis, Giorgos, Laj, P., G. W. Mann, Jennings, S.G., Hamed, A., Weingartner, E., Krejci, R., Carslaw, Kenneth S., Lihavainen, H., Wiedensohler, A., Harrison, R. M., Sun, J., Birmili, W., Mann, Graham W., Bonn, B., Kivekäs, N., Komppula, Mika, Spracklen, Dominick V., Merikanto, Joonas, Laj, Paolo, Hamed, Amar, Jennings, S. G., E. Weingartner, Weingartner, Ernest, Laakso, L., J. A. Ogren, Minikin, A., R. Krejci, Gras, John, S. Pickering, Reddington, C. L., Harrison, R.M., Jennings, Stephen G., Pickering, Steven, H. Lihavainen, B. Bonn, C. O'Dowd, Weller, R., Kulmala, M., N. Mihalopoulos, J. Sun, G. Kouvarakis, Kouvarakis, G., E. Andrews, D. V. Spracklen, Bonn, Boris, Lihavainen, H.Finnish Meteorol. Inst.,, Laaksonen, Ari, C. L. Reddington, Krejci, Radovan, Harrison, Roy Michael, R. Weller   +117 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Intrinsic speckle noise in in-line particle holography due to poly-disperse and continuous particle sizes

, 2000
In-line particle holography is subject to image deterioration due to intrinsic speckle noise. The resulting reduction in the signal to noise ratio (SNR) of the replayed image can become critical for applications such as holographic particle velocimetry ...
Rodgers, GJ, Edwards, PJ, Hobson, PR
core  

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source