Results 81 to 90 of about 5,670,228 (254)

SUCELL Test Conditions Optimization of HELOS/BF Laser Particle Size Analyzer

open access: yesYankuang ceshi, 2013
The Laser Particle Size Analyzer is being more widely used due to its fast test speed, convenient operation and good repeatability, to name a few of its qualities.
LU Xin-cheng, CAO Jing-yang
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

INFLUENCE OF SHAPE AND SIZE OF PARTICLES ON THE OSSEOINTEGRATION OF POROUS IMPLANTS MADE OF TITANIUM POWDER

open access: yesДоклады Белорусского государственного университета информатики и радиоэлектроники, 2019
The results of studies of the effect of particle size, pore size, shape, metallic-ray powder osteointergatsii quality (germination of bone tissue into the pores of the implant) are given.
M. V. Tumilovich   +2 more
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Size distributions in irreversible particle aggregation

open access: yesChemical Physics Impact
The aggregation of particles in the free molecular regime is determined approximately for situations with a high degree of translational energy equilibration. The mean particle sizes develop linearly in time. Scaling relations are used to derive a linear
Klavs Hansen
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Particle size tuning in silver-polyacrylonitrile nanocomposites

open access: yeseXPRESS Polymer Letters, 2010
Silver-polyacrylonitrile (Ag-PAN) nanocomposites were in situ synthesized by simultaneous polymerization of acrylonitrile and reduction of silver ions, starting from mixtures of silver nitrate (AgNO3), acrylonitrile (AN), and UV photoinitiator (IN).
doaj   +1 more source

Liming of forest soils: effectiveness of particle-size fractions

open access: yesJournal of Forest Science, 2002
The paper studies the effect of a single use of a textural fraction of dolomitic limestone (5.1 t per ha) on soil reaction (pH/KCl and pH/H2O) and the content of exchangeable Ca and Mg (in the soil layer of 0-30 cm or in F, H and A horizons) during a 6 ...
L. Musil, V. Pavlíček
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

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