Results 51 to 60 of about 2,195,420 (349)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Simple relativistic model of a finite-size particle [PDF]

, 1993
Soluble model of a relativistic particle describing a bag of matter with fixed radius held together in perfect balance by a self-consistent combination of three forces generated by electromagnetic and massive scalar and vector fields is presented.
Abraham, Bialynicki-Birula, Bialynicki-Birula, Boyer, Dirac, Iwo Bialynicki-Birula, , Kelvin, Lorentz, Miller, Pauli, Pearle, Poincaré, Rohrlich, Rohrlich, Schwartz, Schwartz, Schwartz, Schwinger, Serot, Thomson, von Laue, von Laue, Yaghjian   +22 more
core   +2 more sources

Optimizing particle size for targeting diseased microvasculature: from experiments to artificial neural networks

International Journal of Nanomedicine, 2011
Daniela P Boso1, Sei-Young Lee2, Mauro Ferrari3, Bernhard A Schrefler1, Paolo Decuzzi31Department of Structural and Transportation Engineering, University of Padova, Padova, Italy; 2Global Production Technology Center, Samsung Electronics Co Ltd ...
Schrefler BA, Ferrari M, Lee S, Boso DP, Decuzzi P   +4 more
doaj  

Particle Size Characterization Through Bed Permeability Tests

Chemical Engineering Transactions, 2023
This is an experimental study aiming at understanding the relationship between particle diameters measured with different analytical techniques: optical analysis (microscopy aided by computer image analysis), laser light scattering and permeability tests.
Andrea C. Santomaso, Elisabetta Carazzai, Silvia Volpato   +2 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Pair distribution function and structure factor of spherical particles

, 2006
The availability of neutron spallation-source instruments that provide total scattering powder diffraction has led to an increased application of real-space structure analysis using the pair distribution function.
A. Guinier, F. B. Hildebrand, F. Frey, F. J. Espinosa-Faller, J. B. W. Webber, P. Scherrer, Rafael C. Howell, Steven D. Conradson, Thomas Proffen   +8 more
core   +1 more source

Simultaneous application of soot and temperature measurements in a pressurized turbulent flame by laser-induced incandescence and coherent anti-Stokes Raman scattering for particle sizing [PDF]

, 2023
Klaus Peter Geigle, Hannah Scheffold, Patrick Nau, Zhiyao Yin   +3 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Measuring every particle's size from three-dimensional imaging experiments

, 2012
Often experimentalists study colloidal suspensions that are nominally monodisperse. In reality these samples have a polydispersity of 4-10%. At the level of an individual particle, the consequences of this polydispersity are unknown as it is difficult to
A van Blaaderen, A van Blaaderen, A van Blaaderen, AD Dinsmore, AD Dinsmore, CE Zachary, CJ Dibble, CP Royall, DGAL Aarts, ER Weeks, FC Cheong, HJ Schöpe, J Baumgartl, J Brujić, J Hernández-Guzmán, JA Dijksman, JC Crocker, L Berthier, MC Jenkins, MJ Pond, N Xu, O Ueberschär, P D'Haene, P Rein ten Wolde, P Sollich, PJ Steinhardt, PN Pusey, PN Pusey, R Kurita, R Kurita, RPA Dullens, S Asakura, S Auer, S Slotterback, S-H Lee, SI Henderson, T Kawasaki, T Narumi, U Gasser, V Prasad, VJ Anderson, WCK Poon, WK Kegel, Y Gao   +43 more
core   +1 more source