Results 61 to 70 of about 2,195,420 (349)

Analysis and Application of Particle Backtracking Algorithm in Wind–Sand Two-Phase Flow Using SPH Method

Applied Sciences
Due to the high sensitivity of grid-based micro-scale wind–sand flow models to deformation and distortion, this study employs the Smooth Particle Hydrodynamics (SPH) method for numerical simulations.
Wenxiu Gao, Afang Jin, Zhenguo An, Ming Yan   +3 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Sheathless Size-Based Acoustic Particle Separation

Sensors, 2012
Particle separation is of great interest in many biological and biomedical applications. Flow-based methods have been used to sort particles and cells. However, the main challenge with flow based particle separation systems is the need for a sheath flow ...
Jiang Zhe, Myeong Chan Jo, Nathan D. Gallant, Utkan Demirci, Rasim Guldiken   +4 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

ESTIMATING SOIL PARTICLE-SIZE DISTRIBUTION FOR SICILIAN SOILS

Journal of Agricultural Engineering, 2009
The soil particle-size distribution (PSD) is commonly used for soil classification and for estimating soil behavior. An accurate mathematical representation of the PSD is required to estimate soil hydraulic properties and to compare texture measurements ...
Vincenzo Bagarello, Vito Ferro, Giuseppe Giordano   +2 more
doaj   +1 more source

Adiponectin and Lipoprotein Particle Size

Diabetes Care, 2009
OBJECTIVE Adiponectin has been postulated to affect lipid and insulin signal transduction pathways. We evaluated the relationships of plasma adiponectin with lipoprotein mean particle size and subclass concentrations, independent of obesity and insulin sensitivity ...
Weiss, Ram, Otvos, James D, Flyvbjerg, Allan, Miserez, Andre R, Frystyk, Jan, Sinnreich, Ronit, Kark, Jeremy D   +6 more
openaire   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Brittle-tough transition in nylon-rubber blends: effect of rubber concentration and particle size [PDF]

, 1987
Blends of nylon-6 and EPDM-rubber were prepared with various rubber contents (0–20 wt%) and particle sizes (0.3–1.6 μm). The effects of rubber concentration and particle size on the tensile modulus, torsion modulus, yield stress and notched impact ...
Borggreve, R.J.M., Gaymans, R.J., Ingen Housz, J.F., Schuijer, J.   +3 more
core   +3 more sources

Moment Dynamics of Zirconia Particle Formation for Optimizing Particle Size Distribution

Nanomaterials, 2019
We study the particle formation process of Zirconia ( ZrO 2 )-based material. With a model-based description of the particle formation process we aim for identifying the main growth mechanisms for different process parameters.
Wolfgang Halter, Rahel Eisele, Dirk Rothenstein, Joachim Bill, Frank Allgöwer   +4 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source