Results 51 to 60 of about 167,218 (270)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A New Metaheuristic Bat-Inspired Algorithm

, 2010
Metaheuristic algorithms such as particle swarm optimization, firefly algorithm and harmony search are now becoming powerful methods for solving many tough optimization problems.
J. Kennedy, J.D. Altringham, J.H. Holland, K. Deep, M. Mitchell, P. Richardson, S. Kirkpatrick, T. Colin, X.-S. Yang, Z.W. Geem   +9 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Adaptive hybrid optimization strategy for calibration and parameter estimation of physical models

, 2011
A new adaptive hybrid optimization strategy, entitled squads, is proposed for complex inverse analysis of computationally intensive physical models. The new strategy is designed to be computationally efficient and robust in identification of the global ...
Atmadji, Carrera, Clerc, Cooren, Dahlin, Dawkins, Digalakis, Dokou, Dylan R. Harp, Ghaffari-Miab, Griewank, Harp, Jessell, Krasnogor, Lagarias, Levenberg, Locatelli, Marquardt, Meek, Moscato, Nelder, Nocedal, Pan, Poeter, Poeter, Rao, Rosenbrock, Shang, Snodgrass, Sun, Velimir V. Vesselinov, Vesselinov, Vrugt, Wang, Wilson, Zhang   +35 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Firefly Algorithms for Multimodal Optimization [PDF]

, 2009
Nature-inspired algorithms are among the most powerful algorithms for optimization. This paper intends to provide a detailed description of a new Firefly Algorithm (FA) for multimodal optimization applications.
Yang, Xin-She
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Hybrid chaos-based particle swarm optimization-ant colony optimization algorithm with asynchronous pheromone updating strategy for path planning of landfill inspection robots

International Journal of Advanced Robotic Systems, 2019
Robots are coming to help us in different harsh environments such as deep sea or coal mine. Waste landfill is the place like these with casualty risk, gas poisoning, and explosion hazards.
Peng Chen, Qing Li, Chao Zhang, Jiarui Cui, Hao Zhou   +4 more
doaj   +1 more source

A Fast Globally Convergent Particle Swarm Optimization for Defect Profile Inversion Using MFL Detector

Machines, 2022
For the problem of defect inversion in magnetic flux leakage technology, a fast, globally convergent particle swarm optimization algorithm based on the finite-element forward model is introduced as an inverse iterative algorithm in this paper.
Senxiang Lu, Jinhai Liu, Jing Wu, Xuewei Fu   +3 more
doaj   +1 more source