Results 41 to 50 of about 56,161 (302)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Particle swarm optimization aided orthogonal forward regression for unified data modeling [PDF]
, 2010 We propose a unified data modeling approach that is equally applicable to supervised regression and classification applications, as well as to unsupervised probability density function estimation.
Xia Hong +5 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A Modified Particle Swarm Optimization Algorithm
Journal of Computers, 2009 A modified particle swarm optimization algorithm is proposed in this paper. In the presented algorithm, every particle chooses its inertial factor according to the approaching degree between the fitness of itself and the optimal particle. Simultaneously, a random number is introduced into the algorithm in order to jump out from local optimum and a ...
openaire +1 more source
Feedback learning particle swarm optimization
, 2011 This is the author’s version of a work that was accepted for publication in Applied Soft Computing. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may ...
Tang, Y +5 more
core +1 more source
AMPSO: A new Particle Swarm Method for Nearest Neighborhood Classification [PDF]
, 2009 Nearest prototype methods can be quite successful on many pattern classification problems. In these methods, a collection of prototypes has to be found that accurately represents the input patterns.
Galván, Inés M. +2 more
core +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
The Design and Application of Quantum-Behaved Particle Swarm Optimization Based on Levy Flight
Chemical Engineering Transactions, 2016 Both Particle Swarm Optimization (PSO) and its improved version of Quantum-behaved Particle Swarm Optimization (QPSO) are the novel swarm intelligence optimization algorithms.
Y.Y. Liu
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
The Assessment of Straightness and Flatness Errors Using Particle Swarm Optimization
, 2013 The straightness and flatness errors are generally assessed by using the Least Squares Method (LSM). However, the results obtained from LSM often overestimate the tolerances, and are not consistent with the ISO standards’ definitions.
Cui, Changcai +10 more
core +1 more source