Results 51 to 60 of about 56,161 (302)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Application of Parallel Particle Swarm Optimize Support Vector Machine Model Based on Hadoop Framework in the Analysis of Railway Passenger Flow Data in China

Chemical Engineering Transactions, 2015
In recent years, the development of high-speed railway industry in China is very rapid. However, the development of Chinese high speed railway cannot be further improved without basic research. The passenger flow is the basis and foundation to build high-
W. Xun, Y.B. An, R. Jie
doaj   +1 more source

A satellite selection algorithm based on adaptive simulated annealing particle swarm optimization for the BeiDou Navigation Satellite System/Global Positioning System receiver

International Journal of Distributed Sensor Networks, 2021
In this article, we propose a new particle swarm optimization–based satellite selection algorithm for BeiDou Navigation Satellite System/Global Positioning System receiver, which aims to reduce the computational complexity of receivers under the multi ...
Ershen Wang, Caimiao Sun, Chuanyun Wang, Pingping Qu, Yufeng Huang, Tao Pang   +5 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Reactive Power Optimization Strategy of Power Grid Incorporating Renewable Energy Based on Interval Modeling

南方能源建设, 2021
[Introduction] New energy power generation is intermittent and random, and its power is uncertain data, which will cause changes in grid voltage and frequency, thus pose a threat to the safe operation of the power system. In order to ensure the safety of
WANG Zhongfu
doaj   +1 more source

Discrete Particle Swarm Optimization for the minimum labelling Steiner tree problem

, 2008
Particle Swarm Optimization is an evolutionary method inspired by the social behaviour of individuals inside swarms in nature. Solutions of the problem are modelled as members of the swarm which fly in the solution space.
N. Mladenović, Darby-Dowman, K, Moreno-Pérez, J A, S. Consoli, J. A. Moreno Pérez, Mladenović, N, K. Darby-Dowman, Consoli, S, Moreno-Pérez, JA   +8 more
core   +1 more source

A clustering particle swarm optimizer for dynamic optimization [PDF]

, 2009
This article is posted here with permission of the IEEE - Copyright @ 2009 IEEEIn the real world, many applications are nonstationary optimization problems.
Yang, S, Li, Changhe, Shengxiang Yang, Yang, Shengxiang, Changhe Li, Li, C   +5 more
core   +1 more source

Field Report from Collaborative Research Center 1625: Heterogeneous Research Data Management Using Ontology Representations

Advanced Engineering Materials, EarlyView.
A unified research data management framework for heterogeneous materials data is presented. The system integrates multimodal datasets using ontologies and knowledge graphs, enabling interoperability and FAIR (findable, accessible, interoperable, reusable) data principles. By linking data across scales and workflows, it supports reproducible, Artifitial
Doaa Mohamed, Samuel García Vázquez, Behnam Mardani, Victor Dudarev, Alfred Ludwig, Maribel Acosta, Markus Stricker   +6 more
wiley   +1 more source

A Combined Particle Swarm Optimization Algorithm Based on the Previous Global Best and the Global Best Positions [PDF]

IJCI International Journal of Computers and Information, 2007
This paper introduces a combined algorithm to particle swarm based optimization and discusses the results of experimentally comparing the performances of its three versions with the performance of the particle swarm optimizer.
Mahmoud El-Sherbiny
doaj   +1 more source