Results 51 to 60 of about 127,682 (291)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

The Design and Application of Quantum-Behaved Particle Swarm Optimization Based on Levy Flight

open access: yesChemical Engineering Transactions, 2016
Both Particle Swarm Optimization (PSO) and its improved version of Quantum-behaved Particle Swarm Optimization (QPSO) are the novel swarm intelligence optimization algorithms.
Y.Y. Liu
doaj   +1 more source

Evolutionary estimation of a Coupled Markov Chain credit risk model [PDF]

open access: yes, 2009
There exists a range of different models for estimating and simulating credit risk transitions to optimally manage credit risk portfolios and products.
A. Brabazon   +12 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Reactive Power Optimization Strategy of Power Grid Incorporating Renewable Energy Based on Interval Modeling

open access: yes南方能源建设, 2021
[Introduction] New energy power generation is intermittent and random, and its power is uncertain data, which will cause changes in grid voltage and frequency, thus pose a threat to the safe operation of the power system. In order to ensure the safety of
WANG Zhongfu
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Application of Parallel Particle Swarm Optimize Support Vector Machine Model Based on Hadoop Framework in the Analysis of Railway Passenger Flow Data in China

open access: yesChemical Engineering Transactions, 2015
In recent years, the development of high-speed railway industry in China is very rapid. However, the development of Chinese high speed railway cannot be further improved without basic research. The passenger flow is the basis and foundation to build high-
W. Xun, Y.B. An, R. Jie
doaj   +1 more source

A satellite selection algorithm based on adaptive simulated annealing particle swarm optimization for the BeiDou Navigation Satellite System/Global Positioning System receiver

open access: yesInternational Journal of Distributed Sensor Networks, 2021
In this article, we propose a new particle swarm optimization–based satellite selection algorithm for BeiDou Navigation Satellite System/Global Positioning System receiver, which aims to reduce the computational complexity of receivers under the multi ...
Ershen Wang   +5 more
doaj   +1 more source

Adaptive particle swarm optimization [PDF]

open access: yes, 2009
An adaptive particle swarm optimization (APSO) that features better search efficiency than classical particle swarm optimization (PSO) is presented. More importantly, it can perform a global search over the entire search space with faster convergence ...
Henry Shu-hung Chung   +6 more
core   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

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