Results 51 to 60 of about 81,757 (265)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Target tracking algorithm for wireless sensor networks based on particle swarm optimization and metropolis-hasting sampling particle filter

open access: yesTongxin xuebao, 2013
For the characteristic of the nonlinear relationship between the observation information of sensor nodes and the target dynamic parameters under the real application conditions, a target tracking algorithm for wireless sensor networks based on particle ...
Peng JIANG, Hua-hua SONG, Guang LIN
doaj  

Optimized UAV object tracking framework based on Integrated Particle filter with ego-motion transformation matrix

open access: yesMATEC Web of Conferences, 2017
Vision based object tracking problem still a hot and important area of research specially when the tracking algorithms are performed by the aircraft unmanned vehicle (UAV). Tracking with the UAV requires special considerations due to the flight maneuvers,
Askar Wesam   +3 more
doaj   +1 more source

Particle detection and tracking with DNA

open access: yesEuropean Physical Journal C: Particles and Fields, 2022
We present the first proof-of-concept simulations of detectors using biomaterials to detect particle interactions. The essential idea behind a “DNA detector” involves the attachment of a forest of precisely-sequenced single or double-stranded nucleic ...
Ciaran A. J. O’Hare   +10 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

PARTICLE FILTER BASED VEHICLE TRACKING APPROACH WITH IMPROVED RESAMPLING STAGE [PDF]

open access: yesICTACT Journal on Image and Video Processing, 2014
Optical sensors based vehicle tracking can be widely implemented in traffic surveillance and flow control. The vast development of video surveillance infrastructure in recent years has drawn the current research focus towards vehicle tracking using high ...
Wei Leong Khong   +4 more
doaj  

Coronary Artery Target Tracking Algorithm Based on Feature Matching and Improved Particle Filtering [PDF]

open access: yesJisuanji gongcheng, 2018
Automatic tracking and segmentation of coronary arteries in Computed Tomographic Angiography(CTA) sequence images have clinical significance and especially can help cardiologists make intuitive and rapid diagnosis.According to the characteristics of CTA ...
WANG Guanglei,LU Qian,LIU Xiuling,WANG Pengyu
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

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