Results 41 to 50 of about 238,378 (313)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

FLUKA: A Multi-Particle Transport Code [PDF]

open access: yes, 2005
This report describes the 2005 version of the Fluka particle transport code. The first part introduces the basic notions, describes the modular structure of the system, and contains an installation and beginner's guide.
Sala, P. R.   +3 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Fundamentals of Charged Particle Transport in Gases and Condensed Matter [PDF]

open access: yes, 2017
[Extract] The foundations of modern transport theory were laid 150 years ago in a seminal paper presented to the Royal Society of London by J. Clerk Maxwell.
White, Ron   +2 more
core  

Direct Observation of Inward Electron Flux being Blocked in the Large Helical Device

open access: yes, 2006
We present a particle transport phenomenon caused by a hydrogen ice pellet injection (PI) into the Large Helical Device. The electron density (ne) profile evolution after a PI was measured by using a 200-channel Thomson scattering diagnostic.
YOKOYAMA, Masayuki   +7 more
core   +2 more sources

Simulating Three-Wave Interactions and the Resulting Particle Transport Coefficients in a Magnetic Loop

open access: yesPhysics, 2022
In this paper, the effects of wave–wave interactions of the lowest order, i.e., three-wave interactions, on parallel-propagating Alfvén wave spectra on a closed magnetic field line are considered.
Seve Nyberg, Rami Vainio
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Improved modelling of SEP event onset within the WSA–Enlil–SEPMOD framework

open access: yesJournal of Space Weather and Space Climate
Multi-spacecraft observations of solar energetic particle (SEP) events not only enable a deeper understanding and development of particle acceleration and transport theories but also provide important constraints for model validation efforts.
Palmerio Erika   +16 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

The effects of realistic pancake solenoids on particle transport [PDF]

open access: yes, 2011
Solenoids are widely used to transport or focus particle beams. Usually, they are assumed as being ideal solenoids with a high axial-symmetry magnetic field.
Pikin, A.   +9 more
core   +1 more source

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