Results 121 to 130 of about 7,641,603 (287)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Relación entre Emisiones Contaminantes, Crecimiento Económico y Consumo de Energía. El caso de Ecuador 1971-2010

open access: yesRevista Politécnica, 2016
: The objective of this study is to investigate the relationship between pollutant emissions, economic growth and energy consumption in Ecuador for the period 1971-2010. The methodology is based in econometrics time series involving the same stationarity
Victor Renteria   +3 more
doaj  

Minutes of the Particular Synod of New Brunswick : convened at ...

open access: yes
Description based on: 1881; imprint varies.Mode of access: Internet.New York Genealogical and Biographical ...
Reformed Church in America. Particular Synod of New Brunswick.
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Aquella particular noche de San Juan

open access: yes, 2010
Relato ganador del VII concurso de literatura de la UCM "La Biblioteca de Babel"Depto. de Biblioteconomía y DocumentaciónFac.
Campo Puerta, Pilar del
core  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Primer registro de Ardea cocoi (Pelecaniformes: Ardeidae) en la región Andina del sur de Ecuador

open access: yesCedamaz, 2018
Ardea cocoi (Garzón Cocoi) es una de las garzas de mayor tamaño de Ecuador, se consi- dera común bajo los 400 m s.n.m. en la Ama- zonía norte y gran parte de la costa centro sur del país, siendo inusuales los registros fuera de su área de distribución ...
Leonardo Ordóñez-Delgado   +3 more
doaj  

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