Results 191 to 200 of about 4,224,729 (260)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Counting Spinal Phylogenetic Networks. [PDF]

Bull Math Biol
Francis A, Hendriksen M.
europepmc   +1 more source

Chemical and Enantioselective Analysis of the Leaf Essential Oil from <i>Varronia crenata</i> Ruiz & Pav. Growing in Ecuador. [PDF]

Molecules
Cazares K, Maldonado YE, Cumbicus N, Gilardoni G, Malagón O.   +4 more
europepmc   +1 more source

Changing Gender Relations in Canada: The Rise of Gender-Neutral Forenames. [PDF]

Can Rev Sociol
Guppy N, Kolpashnikova K.
europepmc   +1 more source

Flavor Compounds Identification and Reporting. [PDF]

Molecules
Jeleń HH.
europepmc   +1 more source

Notch2, a Key Player in Chronic Lymphocytic Leukemia: Mechanism, Microenvironment Interactions, and Therapeutic Implications. [PDF]

Cancers (Basel)
Miserendino R, Atene CG, Luppi M, Marasca R, Fiorcari S.   +4 more
europepmc   +1 more source

Analysis of Multilevel Factors Mobilizing the Spectrum of Interorganizational Knowledge Sharing for Facilitating Digital Transformation at Scale: Qualitative Study.

J Med Internet Res
Mozaffar H, Williams R, Cresswell K.
europepmc   +1 more source

Correction: A bibliometric analysis and systematic review of drug repurposing against drug-resistant ESKAPE pathogens: a particular focus on <i>Pseudomonas aeruginosa</i>. [PDF]

Front Microbiol
Frontiers Production Office.
europepmc   +1 more source