Results 71 to 80 of about 25,407 (286)
CoSMO, 2021 Until half a century ago, the question “what is literature?” was common in literary studies. Today such questions have something naïve, especially in a time that has become sceptical towards theories. This article tries to avoid this naïve side starting from two books that have enquired into the question ‘what is literature’, in an analytical and ...
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
"Vårt liv drar bort i förvandling"
Tidskrift för Litteraturvetenskap, 2015 ”Our Life Glides By in Transformation”. Literature and Scholarship in the Flux of Time This article – originally a sexagenarian lecture – first considers the transience of the inner life of human beings, bringing out the unique ability of literature ...
Torsten Pettersson
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Ergo an Open Access Journal of PhilosophyWe spend much of our adult lives thinking and reminiscing about particular events of the past, which, by their very nature, can never be repeated. What is involved in a capacity to think thoughts of this kind? In this paper, I propose that such thoughts are essentially connected with a capacity to communicate about past events, and specifically in the ...
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
The Appropriation of Space [PDF]
, 2010 In this paper, I study some aspects of urban environment using the concept of non-place intro- duced by Marc Augé in 1995. I first define the concepts of space, place and non-place.
Bruchansky, Christophe
core
Genetic Programming Theory and Practice ...
Spector, Lee, Ding, Li, Boldi, Ryan
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Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Cadernos de Saúde Pública, 2002 Com base em uma discussão de autores contemporâneos sobre a formação histórica do Brasil e sua incorporação ao projeto de sociedade moderna, o artigo identifica duas formas de particularismo o das diferenças e o das relações pessoais que na esfera ...
Jeni Vaitsman
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