Results 101 to 110 of about 1,901,965 (297)

Policy Guide For Municipal Leaders and Legislators [PDF]

, 2013
This Guide for Municipal Leaders and Legislators, is a companion to the full 2013 State of Our Estuaries Report, and focuses more specifically on what state and local leaders can do to improve environmental conditions in the estuaries.
Piscataqua Region Estuaries Partnership
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Protecting Wildlife and Significant Habitat in Coastal New Hampshire [PDF]

, 2003
The Great Bay Resource Protection Partnership (“Partnership”) consists of organizations and agencies that are committed to protecting the important habitats of the Great Bay area.
Nature Conservancy
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Knowledge mobilisation for chronic disease prevention: the case of the Australian Prevention Partnership Centre

Health Research Policy and Systems, 2018
Background Cross-sectoral, multidisciplinary partnership research is considered one of the most effective means of facilitating research-informed policy and practice, particularly for addressing complex problems such as chronic disease.
Sonia Wutzke, Samantha Rowbotham, Abby Haynes, Penelope Hawe, Paul Kelly, Sally Redman, Seanna Davidson, Jackie Stephenson, Marge Overs, Andrew Wilson   +9 more
doaj   +1 more source

Ctizen: What You Can Do to Help Improve Our Estuaries [PDF]

, 2013
The need to keep our Seacoast rivers, lakes, marshes and Great Bay free of pollution is something we can all agree on. As the Community for Clean Water, PREP works to unite and encourage you, your friends and family to take simple steps to reduce water ...
Piscataqua Region Estuaries Partnership
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Developing an inter-university partnership: The importance of relationally-connected leaders [PDF]

, 2014
We have been involved in an inter-university partnership that supports, contributes to, and influences our own and others’ thinking and actions. As we have collaborated on teaching, learning, and research in the field of educational leadership, we ...
Ferrier-Kerr, Jenny L., Haxton, Paul
core   +2 more sources