Results 141 to 150 of about 51,758 (256)

Mechanism‐Based Polypharmacy as a Repurposing Strategy: The Case of D‐Cycloserine and Lurasidone

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Modern psychiatric treatment often necessitates polypharmacy, yet combination regimens carry significant risks of metabolic burden and drug–drug interactions. There is growing interest in and clinical acceptance of rational, mechanism‐based drug combinations that are designed around desirable pharmacological properties rather than trial and ...
Avery D. Franzen, John S. Svendsen, Cassidy J. Kline, Susan Q. Shen   +3 more
wiley   +1 more source

Interlaboratory study on real-time PCR detection and quantification of the European anglerfish, pike, and seabream parvalbumin gene

This study presents a large-scale interlaboratory comparison (ILC) aimed at detecting and quantifying DNA from two European anglerfish (Lophius budegassa, Lophius piscatorius), pike (Esox lucius) and sea bream (Spondyliosoma cantharus) using real-time ...
Marin, Marco A. Lopez, Kýrová, Veronika, Potůčková, Miroslava, Horká, Petra, Čermáková, Eliška, Mukherjee, Subham, Zdeňková, Kamila   +6 more
core   +1 more source

Padrão da expressão de proteínas ligantes de cálcio e receptores de glutamato do tipo AMPA em núcleos pré-tectais de pintos (Gallus domesticus) [PDF]

, 2000
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Mestrado em NeurociênciasUma das características da visão perfeita é a capacidade de fixar o olhar sobre o alvo desejado.
Santos, Rita de Cássia dos
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Metal Ion Binding to Parvalbumin : A Proton NMR Study

, 1986
The 1H NMR spectra of carp parvalbumin saturated with Ca2+, Cd2+, La3+ and Lu3+ were compared, using 2D 1H NMR techniques as well as conventional 1H NMR spectra. The Ca2+ and Cd2+ saturated parvalbumin (with both high affinity Ca2+-binding sites occupied)
C. R. Enzell, T. Drakenberg, R. Ryhage, R. Isaksson, E.M. Ragg, A. Cavé, S. Liaaen Jensen   +6 more
core   +1 more source

Multifiber Array‐Based Photometry System for Multiregional Functional Mapping in the Mouse Brain

European Journal of Neuroscience, Volume 63, Issue 12, June 2026.
Existing fiber photometry approaches suffer from invasiveness and limited scalability. A newly developed multifiber array‐based photometry system allows targeting multiple brain regions with less invasiveness. The system was validated in two jGCaMP8s‐expressing mouse lines by monitoring GABAergic neural population activity across multiple brain regions
Manil Bradai, Mirna Merkler, Gabriela Gil, Rebecca Davie, Shuzo Sakata   +4 more
wiley   +1 more source

Calcium Buffering in Astrocytes and Its Relevance for Experimental Data Interpretation and Computational Modeling

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Components and properties of Ca2+ buffers in astrocytes, which should be considered for data interpretation and in computational modeling of astrocyte Ca2+ activity. ABSTRACT Astrocytic Ca2+ signaling is essential for maintaining physiological brain function, including the modulation of synaptic transmission, neurovascular coupling, and ion homeostasis.
Kerstin Lenk, Andre Zeug, Franziska E. Müller   +2 more
wiley   +1 more source

Early adversity and the comorbidity between metabolic disease and psychopathology

The Journal of Physiology, Volume 604, Issue 11, Page 4338-4377, 1 June 2026.
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas, Patricia Pelufo Silveira   +1 more
wiley   +1 more source

Loss of Striatal Bradykinin B2 Receptor Alters Anxiety and Motivational Behaviors in Male Mice

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Impaired signaling of the bradykinin B2 receptor (B2R) in dorsal striatal neurons decreases anxiety‐like behavior and sucrose preference while enhancing voluntary running in mice. These results reveal a novel role for B2R in dopaminergic circuits that modulate motivation and emotional behavior.
Mariana Rosolen Tavares, Ronaldo Carvalho Araujo, Marina Galleazzo Martins, Jose Donato Jr, Michael Bader, Frederick Wasinski   +5 more
wiley   +1 more source

Localization of the Ca(2+)-binding alpha-parvalbumin and its mRNA in epiphyseal plate cartilage and bone of growing rats.

, 1995
International audienceThis study describes the localization of alpha-parvalbumin, in undecalcified tibial epiphyseal cartilage and bone of growing rats by immunocytochemistry in the light microscope, and of parvalbumin mRNA by in situ hybridization. They
Belqasmi, F., Hauchecorne, M., Toury, R., Leguellec, D., Heizmann, Cw, Balmain, N.   +5 more
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Parvalbumin Gene Transfer Impairs Skeletal Muscle Contractility in Old Mice

, 2012
Parvalbumin Gene Transfer Impairs Skeletal Muscle Contractility in Old ...
Jennifer Trieu (535281), Timur Naim (535284), Daniel J Ham (19187800), Kate Murphy (13086459), Jarrod E Church (19473448), Gordon S Lynch (13620712), David A Williams (19473451)   +6 more
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