Results 121 to 130 of about 51,758 (256)
<i>Background:</i> Although 95% of fish-allergic patients are sensitized to the major fish allergen parvalbumin, clinical reactions to different fish species vary considerably in symptoms, intensity and frequency in allergic subjects.
T. Scheuermann +3 more
core +1 more source
Unilateral prefrontal TILS reliably increases ipsilateral cytochrome‐c‐oxidase and oxygenated hemoglobin, demonstrating dose‐dependent metabolic efficacy without adverse effects. Contralateral responses are asymmetric: changes emerge later and differ by stimulation side, with stronger right‐hemisphere effects after left‐sided TILS, suggesting ...
Patrick O'Connor +4 more
wiley +1 more source
Infralimbic parvalbumin neural activity facilitates cued threat avoidance
The infralimbic cortex (IL) is essential for flexible behavioral responses to threatening environmental events. Reactive behaviors such as freezing or flight are adaptive in some contexts, but in others a strategic avoidance behavior may be more ...
Yi-Yun Ho +4 more
doaj +1 more source
Structural Characterization of Parvalbumin from an Antarctic Notothenioid Fish Species
Parvalbumins are proteins that buffer intracellular calcium concentrations and facilitate muscle relaxation. They are important in fish white muscle, which powers burst-speed swimming.
Hendrickson, Jamie Willis
core
The three-dimensional structure of parvalbumin from leopard shark (Triakis semifasciata) with 109 amino acid residues (alpha-series) is described at 1.54 A resolution. Crystals were grown at 20 degrees C from 2.9 M-potassium/sodium phosphate solutions at
Rambaud, J. +4 more
core +1 more source
A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang +15 more
wiley +1 more source
Stable neuronal representations underlie cognitive resilience to Alzheimer's disease pathology
Abstract INTRODUCTION While Alzheimer's disease (AD) typically elicits progressive cognitive decline, some individuals with significant AD pathology maintain cognition. Understanding the neuronal underpinnings of such cognitive resilience would propel the development of interventions for delaying dementia.
Keying Chen +9 more
wiley +1 more source
The complete amino acid sequence of bullfrog (Rana catesbeiana) parvalbumin pI4.97
The primary structure of the parvalbumin (pI4.97) from bullfrog, Rana catesbeiana, skeletal muscle has been determined. It is composed of 110 amino acid residues and a free amino terminus, and has a molecular mass of 11919.
Tanokura, Masaru +5 more
core +1 more source
Channel Dysfunction as the Basis for Comorbidities in Multiple Sclerosis and Depression
Ion channel remodelling induced by neuroinflammation in multiple sclerosis alters neuronal excitability and immune signalling, creating shared molecular pathways that link multiple sclerosis pathology to depression and reveal novel pharmacological targets.
Nicole Rychlik +4 more
wiley +1 more source
Parvalbumin interneuron deficits in schizophrenia
Parvalbumin-expressing (PV+) interneurons represent one of the most abundant subclasses of cortical interneurons. Owing to their specific electrophysiological and synaptic properties, PV+ interneurons are essential for gating and pacing the activity of excitatory neurons.
openaire +2 more sources

