Results 41 to 50 of about 433,714 (266)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Passive control strategy of inductive power transfer to microimplants based on ferroelectric dielectrics

open access: yesCurrent Directions in Biomedical Engineering
In this study, a passive control strategy of inductive power transfer (IPT) using ferroelectric multilayer ceramic chip capacitors (MLCCs) is presented.
Olsommer Yves, Ihmig Frank R.
doaj   +1 more source

Passivity-Based Control [PDF]

open access: yes, 2019
Stabilization of physical systems by shaping their energy function is a well-established technique whose roots date back to the work of Lagrange and Legendre. Potential energy shaping for fully actuated mechanical systems was first introduced in Takegaki and Arimoto (Trans ASME J Dyn Syst Meas Control 12:119--125, 1981) more than 30 years ago.
Ortega, Romeo, Borja, Pablo
openaire   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Effect of Vinyl Flooring on the Modal Properties of a Steel Footbridge

open access: yesApplied Sciences, 2019
Damping ratios associated with non-structural elements play an important role in mitigating the pedestrian-induced vibrations of slender footbridges.
Javier Fernando Jiménez-Alonso   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Proliferation of Human Cervical Cancer Cells Responds to Surface Properties of Bicomponent Polymer Coatings

open access: yesNanomaterials
The proliferation of human cervical cancer (Hela) cells was investigated on a series of nanostructured polymer latex surfaces. The physico-chemical properties of the surfaces, composed of mixtures of polystyrene and acrylonitrile butadiene styrene ...
Emil Rosqvist   +5 more
doaj   +1 more source

Effect of MetaFoundation on the Seismic Responses of Liquid Storage Tanks

open access: yesApplied Sciences, 2022
Cylindrical liquid storage tanks are vital lifeline structures, playing a critical role in industry and human life. Damages to these structures during previous earthquakes indicate their vulnerability against seismic events.
Mostafa Farajian   +2 more
doaj   +1 more source

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