Results 51 to 60 of about 982,375 (281)

Passive Immunization of Farmed Fish [PDF]

The Journal of Immunology, 2017
Abstract The fast growth and potential of global aquaculture has necessitated the adoption of sustainable and welfare-oriented therapeutics and prophylactic strategies. Knowledge gathered from studies about maternal passive immunity in fish and fish-to-fish passive immunization experiments supports the concept of using therapeutic Abs ...
Binoy, Rajan, Guro, Løkka, Erling Olaf, Koppang, Lars, Austbø   +3 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Prepartum Supplementation to Improve Transfer of Passive Immunity and Growth [PDF]

, 2019
Late pregnant cows often experience nutritional stress in northern Australia, which reduces colostrum secretion, health, and likelihood of survival of neonatal calves. The effect of prepartum supplementation on the transfer of passive immunity and growth
Geoffry Fordyce, Silva, Luis F. P., Cavalieri, John, Muller, Jarud, Fordyce, Geoffry, Jarud Muller, Luis F. P. Silva, John Cavalieri   +7 more
core   +3 more sources

Experimental cerebral malaria develops independently of caspase recruitment domain-containing protein 9 signaling.

, 2011
The outcome of infection depends on multiple layers of immune regulation, with innate immunity playing a decisive role in shaping protection or pathogenic sequelae of acquired immunity.
Jan Burgold, Hafalla, J.C., Kai Matuschewski, Julius Clemence R. Hafalla, Gross, Olaf, Jürgen Ruland, Stefan H. E. Kaufmann, Kaufmann, Stefan H. E., Olaf Gross, Hafalla, Julius Clemence R., Gross, O., Matuschewski, K., Matuschewski, Kai, Ruland, Jürgen, Kaufmann, Stefan HE, Ruland, J., Burgold, Jan, Hafalla, Julius Clemence R, Dorhoi, Anca, Burgold, J., Anca Dorhoi, Dorhoi, A., Kaufmann, S.H., Hafalla, JC;Burgold, J;Dorhoi, A;Gross, O;Ruland, J;Kaufmann, SH;Matuschewski, K   +23 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Assessment of BoAHV-1 Seronegative Latent Carrier by the Administration of Two Infectious Bovine Rhinotracheitis Live Marker Vaccines in Calves

Vaccines
Seronegative latent carriers (SNLCs) are animals that carry the virus without detectable antibodies and pose a risk for disease transmission and diagnostic challenges, suggesting the importance of consideration of marker vaccines in managing them ...
Stefano Petrini, Cecilia Righi, Giulia Costantino, Eleonora Scoccia, Paola Gobbi, Claudia Pellegrini, Michela Pela, Monica Giammarioli, Giulio Viola, Roberto Sabato, Elena Tinelli, Francesco Feliziani   +11 more
doaj   +1 more source

Comprehensive serologic profile and specificity of maternal and neonatal cord blood SARS-CoV-2 antibodiesAJOG Global Reports at a Glance

AJOG Global Reports, 2022
BACKGROUND: Initial studies on COVID-19 in pregnancy have demonstrated a range of neutralizing activity, but little has been published on the full profile of SARS CoV-2 related antibodies in maternal and cordblood. OBJECTIVE: This study aimed to describe
Rupsa C. Boelig, MDMS, Sidhartha Chaudhury, PhD, Zubair H. Aghai, MD, Emily A. Oliver, MD, Francesca Mancuso, BA, Vincenzo Berghella, MD, Elke S. Bergmann-Leitner, PhD   +6 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission

Frontiers in Immunology, 2022
IntroductionInfants acquire maternal antibodies by Fc receptor transcytosis across the placenta during pregnancy. Fc receptors are expressed on immune cells and are important for activation of effector cell functions.MethodsIn this study, we evaluated Fc
Brittani M. Barrows, Brittani M. Barrows, Brittani M. Barrows, Shelly J. Krebs, Shelly J. Krebs, Ningbo Jian, Ningbo Jian, Michelle Zemil, Michelle Zemil, Bonnie M. Slike, Bonnie M. Slike, Vincent Dussupt, Vincent Dussupt, Ursula Tran, Ursula Tran, Letzibeth Mendez-Rivera, Letzibeth Mendez-Rivera, David Chang, David Chang, Anne Marie O’Sullivan, Anne Marie O’Sullivan, Brendan Mann, Brendan Mann, Eric Sanders-Buell, Eric Sanders-Buell, Zhanna Shubin, Zhanna Shubin, Matt Creegan, Matt Creegan, Dominic Paquin-Proulx, Dominic Paquin-Proulx, Philip Ehrenberg, Philip Ehrenberg, Agnes Laurence-Chenine, Agnes Laurence-Chenine, Kriengkrai Srithanaviboonchai, Rasmi Thomas, Michael A. Eller, Michael A. Eller, Guido Ferrari, Merlin Robb, Merlin Robb, Venigalla Rao, Sodsai Tovanabutra, Sodsai Tovanabutra, Victoria R. Polonis, Lindsay Wieczorek, Lindsay Wieczorek   +47 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source