Results 131 to 140 of about 80,988 (235)

An Engineered Nano‐Vesicle Adjuvant Platform (ENAP) for Cytokine Delivery Enables a Novel Antigen‐Coordinated Vaccine Against Helicobacter pylori

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Despite the considerable potential of Helicobacter pylori (H. pylori) vaccines, their clinical efficacy has been hampered by inadequate mucosal immunity and suboptimal Th1/Th17 polarization. To address this, we engineered a novel nano‐adjuvant system using LPS‐modified recombinant outer membrane vesicles (rOMVs) derived from H.
Yinpan Shang, Xiran Zhang, Linwei Li, Xiaomin Yu, Lingbing Zeng, Yanli Cao, Ziwei Tao, Lu Shen, Shuaishuai Zhang, Chuangye Yang, Huizhen Tian, Ying Liang, Hanchen Liao, Xiaotian Huang, Qiong Liu   +14 more
wiley   +1 more source

Immunization strategies against respiratory syncytial virus in Panama: considerations for decision-making in a tropical country—a working group meeting report

Frontiers in Public Health
Following the approval of the respiratory syncytial virus (RSV) vaccine and a new monoclonal antibody for passive immunization in children, some Latin American countries have begun using both strategies to prevent RSV-disease.
Xavier Sáez-Llorens, Catherine Lissette Castillo, Danilo Franco, Raúl Esquivel, Kathia Luciani, Rodrigo DeAntonio   +5 more
doaj   +1 more source

Toxic mechanisms of amyloid oligomers and therapeutic strategies

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source

WHAT YOU SHOULD KNOW ABOUT HOG CHOLERA [PDF]

, 1959
I. WHAT IS HOG CHOLERA? Hog cholera is a deadly, contagious disease that attacks swine only. The disease is caused by hog cholera virus, an agent so small (1/250,000 of an inch) that it can even pass through a fine porcelain filter.
Aitken, W.A., Gifford, C.W., Hendershott, R.A., Hutchings, L.M., McNutt, S.H., Quin, A.H., Ray, J.D., Shope, R.E.   +7 more
core   +1 more source

The Risk of Adverse Birth Outcomes Among Twin Pregnancies After Influenza and Pertussis Vaccinations During Pregnancy: A Data Linkage Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 5, Page 1083-1092, April 2026.
ABSTRACT Objective To compare risks of adverse birth outcomes between maternally vaccinated and unvaccinated twin pregnancies. Design Multi‐jurisdictional data linkage cohort study. Setting All registered births in Queensland (Qld) and Northern Territory (NT), Australia between 1 January 2012 and 31 December 2017.
Kahlee Boyle, Sarah Graham, Michael Binks, Lisa McHugh   +3 more
wiley   +1 more source

Engineering Yeast Extracellular Vesicle Biogenesis Through Rewiring Membrane Trafficking Pathways

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
Engineered Saccharomyces cerevisiae reveals how cell wall remodelling and membrane trafficking coordinate extracellular vesicle biogenesis. Interferon overexpression and chs3 deletion enhance EV secretion and reshape SNARE‐, Rab‐ and ESCRT‐associated pathways, establishing yeast as a versatile platform for EV engineering and therapeutic cargo loading ...
Yueyan Li, XiaoRan Ma, Lichao Zhang, Ning Cao, Zhibo Li, Ruixin Khoo, Mei Wang, Changyan Li, Deping Hua, Xintian Zheng, Jinhai Huang, Lilin Zhang   +11 more
wiley   +1 more source

<i>In vitro</i> generated antibodies guide thermostable ADDomer nanoparticle design for nasal vaccination and passive immunization against SARS-CoV-2. [PDF]

Antib Ther, 2023
Buzas D, Bunzel AH, Staufer O, Milodowski EJ, Edmunds GL, Bufton JC, Vidana Mateo BV, Yadav SKN, Gupta K, Fletcher C, Williamson MK, Harrison A, Borucu U, Capin J, Francis O, Balchin G, Hall S, Vega MV, Durbesson F, Lingappa S, Vincentelli R, Roe J, Wooldridge L, Burt R, Anderson RJL, Mulholland AJ, Bristol Uncover Group, Hare J, Bailey M, Davidson AD, Finn A, Morgan D, Mann J, Spatz J, Garzoni F, Schaffitzel C, Berger I.   +36 more
europepmc   +1 more source

Stakeholder Perspectives on Ear and Hearing Health Service Provision for Aboriginal and Torres Strait Islander Children

Australian Journal of Rural Health, Volume 34, Issue 2, April 2026.
ABSTRACT Objective Ear disease and hearing loss are largely preventable; however, Aboriginal and Torres Strait Islander children experience some of the highest rates globally. National and state guidelines recommend involving Aboriginal Health Workers/Practitioners (AHWP) in ear and hearing screening, but no investigation has been conducted into ...
Jacqueline H. Stephens, Brianna F. Poirier, Amanda Machell, Patricia L. Macfarlane, Nicola J. Spurrier, Leanne Quirino   +5 more
wiley   +1 more source

Major Cat Allergen Fel d 4: Structure and Identification of a Cross‐Reactive IgE‐Epitope‐Containing Area

Allergy, Volume 81, Issue 4, Page 1075-1088, April 2026.
This study reports the three‐dimensional structure of an important cat allergen, Fel d 4, that shares high homology with Equ c 1 (i.e., major horse allergen) and Can f 6 (i.e., dog allergen). The C‐terminal region of the Fel d 4 contains a major IgE‐reactive epitope.
Nikolina Todorović, Daria Trifonova, Zicheng Liu, Mirela Curin, Laszlo Schooltink, Theo Sagmeister, Christoph Grininger, Renata Kiss, Nina Gottstein, Bernd Gesslbauer, Andreas Winkler, Tea Pavkov‐Keller, Alexander Karaulov, Rudolf Valenta, Walter Keller   +14 more
wiley   +1 more source

Factors Affecting Immune Reconstitution Post‐Allogeneic HSCT in Children: The Case for an Individualized Approach to Vaccination

European Journal of Haematology, Volume 116, Issue 4, Page 336-349, April 2026.
ABSTRACT Allogeneic hematopoietic stem cell transplantation (HSCT) is increasingly used to treat malignant and non‐malignant diseases. Following allogeneic HSCT, patients are particularly vulnerable to vaccine‐preventable diseases (VPD) because conditioning depletes immune cells, including memory cells.
Hélène Buvelot, Frederic Baleydier, Laure Pittet, Geraldine Blanchard‐Rohner   +3 more
wiley   +1 more source