Clinical Validation of Plasma p‐217tau in Neurological Diseases
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi +13 more
wiley +1 more source
Issues in development, evaluation, and use of the NASA Preflight Adaptation Trainer (PAT) [PDF]
The Preflight Adaptation Trainer (PAT) is intended to reduce or alleviate space adaptation syndrome by providing opportunities for portions of that adaptation to occur under normal gravity conditions prior to space flight. Since the adaptation aspects of
Kennedy, Robert S., Lane, Norman E.
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A framework for empirical discovery [PDF]
, 1986 Previous research in machine learning has viewed the process of empirical discovery as search through a space of 'theoretical' terms. In this paper, we propose a problem space for empirical discovery, specifying six complementary operators for defining ...
Langley, Pat, Nordhausen, Bernd
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Von Economo Neuron Loss in Frontotemporal Dementia: A Meta‐Analysis of Neuropathological Studies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Von Economo neurons (VENs) have been reported to be vulnerable to neurodegeneration in frontotemporal dementia (FTD), particularly the behavioral variant (bvFTD), but these findings have not been systematically assessed across independent brain banks.
Daniel Talmasov +2 more
wiley +1 more source
Cryogenic fluid management (base R/T): Cryogenic fluid systems, Cryogenic Orbital Nitrogen Experiment (CONE), Cryogenic Orbital Hydrogen Experiment (COHE). (Transportation focused technology) [PDF]
The topics presented are covered in viewgraph form. The concluded remarks are: (1) advanced cryogenic fluid systems technology is enhancing or enabling to all known transportation scenarios for space exploration; (2) an integrated/coordinated program ...
Symons, Pat
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Methods of conceptual clustering and their relation to numerical taxonomy [PDF]
, 1985 Artificial Intelligence (AI) methods for machine learning can be viewed as forms of exploratory data analysis, even though they differ markedly from the statistical methods generally connoted by the term.
Fisher, Douglas, Langley, Pat
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A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source
COVID-2019—A Personal Account of an Academic Institute’s Response to the Pandemic
COVIDThe unprecedented introduction and spread of SARS-CoV-2, responsible for the COVID-19 epidemic, had many varied and unanticipated consequences for the United States and other countries.
Stephen Higgs
doaj +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Being an information literate researcher: tips for avoiding plagiarism [PDF]
, 2009 A practical guide by Pat Gannon-Leary and Moira Bent to avoiding plagiarism when gathering information, managing and writing up your research ...
Bent, Moira, Gannon-Leary, Pat
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