Results 91 to 100 of about 1,394,136 (302)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

open access: yesFEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao   +3 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

Dampak Proses Politik dan Konsekuensi Ekonomi dalam Pembentukan Suatu Standar

open access: yesJournal of Accounting and Investment, 2016
Standard setters should consider the possibility of the political process and economic consequences in making standard. The underlying reason is to reduce the presence of the injured party.
Aida Ainul Mardiyah
doaj  

A Medicaid Perspective on Medical Support Cooperation: A Study of Procedures in Five States [PDF]

open access: yes, 2005
Draws from case studies of medical support procedures obtained in Arizona, Connecticut, Minnesota, South Carolina, and Wisconsin to examine how medical support requirements impact parents applying for Medicaid coverage for themselves and their ...
Pat Redmond
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Application of the Naïve Bayes Algorithm in Classifying the Reading Interests of Regional Library Visitors

open access: yesKnowbase
Reading interest is a key indicator in assessing the success of library services. However, manually understanding visitors' preferences poses a challenge for library managers. This study aims to classify the reading interests of regional library visitors
Murlena Murlena, Wandi Syahindra
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Motywy i przejawy posłuszeństwa zasadom Królestwa Bożego

open access: yesVox Patrum, 2008
Der vorliegende Aufsatz zeigt die Motive und Merkmale des Gehorsams gegen Grundsatze des Kónigreichs Gottes. Das Kónigreich Gottes ist die Wirklichkeit des Glaubens, in der Gott der Vater der Liebe und Barmherzigkeit ist.
Stanisław Sojka
doaj  

Solid Subtype of Papillary Thyroid Carcinoma: A Case Series Highlighting Aggressive Features

open access: yesClinical Case Reports
Papillary thyroid carcinoma (PTC) is the most common malignant thyroid neoplasm. Its solid/trabecular subtype (STPTC) is rare, and its aggressiveness remains controversial.
Rafael Castellanos Bueno   +4 more
doaj   +1 more source

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