Results 71 to 80 of about 1,394,136 (302)

PENGEMBANGAN SISTEM INFORMASI AKAD MUDHĀRABAH BANK SYARIAH BERBASIS DSS DENGAN MENGGUNAKAN METODE AHP

open access: yesEconomica: Jurnal Ekonomi Islam, 2016
This research aims to develop a scoring system awarding financial cooperation that existed at Syariah Banking using various contract in it. The development of this system will replace the performance of the analytical assess and decide on the granting of
Setyo Budi Hartono   +2 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

The Scholarship of Teaching and Learning as a Subversive Activity

open access: yesTeaching & Learning Inquiry: The ISSOTL Journal, 2016
One of the most serious challenges facing higher education today is the erosion of academic culture—a declining sense that faculty form a community whose members reflect, deliberate, and make decisions together in the name of a shared educational vision.
David L. Boose, Pat Hutchings
doaj   +1 more source

A cognitive architecture for learning in reactive environments [PDF]

open access: yes, 1986
Previous research in machine learning has viewed the process of empirical discovery as search through a space of 'theoretical' terms. In this paper, we propose a problem space for empirical discovery, specifying six complementary operators for defining ...
Langley, Pat
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Learning style and learning strategies in a multimedia environment [PDF]

open access: yes, 1995
There is a growing realization that it may be expeditious to combine elements from different theories of learning when trying to derive a coherent and usable policy towards computer‐mediated learning.
Paterson, Pat, Rosbottom, John
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Adhesion of antibiotic-resistant bacteria to patient-applied thermoplastic medical devices

open access: yesAntimicrobial Stewardship & Healthcare Epidemiology
Adhesion of antibiotic-resistant bacteria to medical device thermoplastics was evaluated by removal sampling at 1 and 24 hours. Vancomycin-resistant Enterococcus faecalis was removed in greater numbers than either methicillin-resistant Staphylococcus ...
Catherine Brock   +2 more
doaj   +1 more source

Information Decomposition in Bivariate Systems: Theory and Application to Cardiorespiratory Dynamics

open access: yesEntropy, 2015
In the framework of information dynamics, the temporal evolution of coupled systems can be studied by decomposing the predictive information about an assigned target system into amounts quantifying the information stored inside the system and the ...
Luca Faes   +2 more
doaj   +1 more source

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