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Patch clamp techniqueThe patch clamp technique enables the analyses of various ion channel characteristics of individual cells in vitro. The most important difference from previous techniques is that the microelectrode (pipette) is firmly attached to the cell surface instead of being inserted into the cells, and the so-called "giga-ohm seal" is attained. Usually, the whole
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Challenges and Insights in Patch-Clamp Studies: From Cell-Attached to Whole-Cell Configurations
Sheng-Nan Wu +2 more
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Neurosurgery, 1995
The introduction of the patch clamp technique less than two decades ago revolutionized the study of cellular physiology by providing a high-resolution method of observing the function of individual ionic channels in a variety of normal and pathological cell types.
L K, Liem +3 more
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The introduction of the patch clamp technique less than two decades ago revolutionized the study of cellular physiology by providing a high-resolution method of observing the function of individual ionic channels in a variety of normal and pathological cell types.
L K, Liem +3 more
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Drug Discovery Today, 2004
Abstract Many ion channels are recognized as amenable targets for a range of disease states and conditions. However, the process of discovering drugs is highly influenced by the chemical doability, the biological confidence in rationale of the approach and the ‘screenability’.
Claire, Wood +2 more
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Abstract Many ion channels are recognized as amenable targets for a range of disease states and conditions. However, the process of discovering drugs is highly influenced by the chemical doability, the biological confidence in rationale of the approach and the ‘screenability’.
Claire, Wood +2 more
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2013
Ion channels are integral membrane proteins that regulate the flow of ions across the plasma membrane and the membranes of intracellular organelles of both excitable and non-excitable cells. Ion channels are vital to a wide variety of biological processes and are prominent components of the nervous system and cardiovascular system, as well as ...
Carol J, Milligan, Clemens, Möller
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Ion channels are integral membrane proteins that regulate the flow of ions across the plasma membrane and the membranes of intracellular organelles of both excitable and non-excitable cells. Ion channels are vital to a wide variety of biological processes and are prominent components of the nervous system and cardiovascular system, as well as ...
Carol J, Milligan, Clemens, Möller
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1995
In this chapter, I shall explain how to set-up a patch-clamp technique. The aim is to guide researchers in their initial steps in the field of electrophysiology, describing the instrumentation needed, as well as the technique itself. This chapter has been written assuming that the reader has a basic knowledge of electrophysiology.
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In this chapter, I shall explain how to set-up a patch-clamp technique. The aim is to guide researchers in their initial steps in the field of electrophysiology, describing the instrumentation needed, as well as the technique itself. This chapter has been written assuming that the reader has a basic knowledge of electrophysiology.
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Nihon rinsho. Japanese journal of clinical medicine, 1997
Patch clamp technique was applied to variety of cells for variety of purposes. There are several modifications made for the technique and we can now record not only from the single channel but also from the whole cell membrane. The application of the patch recording technique was expanded and recordings were made recently from brain slice preparations.
T, Hashimoto +4 more
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Patch clamp technique was applied to variety of cells for variety of purposes. There are several modifications made for the technique and we can now record not only from the single channel but also from the whole cell membrane. The application of the patch recording technique was expanded and recordings were made recently from brain slice preparations.
T, Hashimoto +4 more
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1983
Ion-channel reconstitution and patch recording offer different but complementary experimental methods. Both can be used to help provide a molecular understanding of how ion transport activity is controlled by protein structure and regulation. On the one hand, through use of reconstitution techniques, an ion channel can be isolated, purified, and/or ...
David W. Tank, Christopher Miller
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Ion-channel reconstitution and patch recording offer different but complementary experimental methods. Both can be used to help provide a molecular understanding of how ion transport activity is controlled by protein structure and regulation. On the one hand, through use of reconstitution techniques, an ion channel can be isolated, purified, and/or ...
David W. Tank, Christopher Miller
openaire +1 more source