Results 71 to 80 of about 740,254 (291)

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Unstructured spline spaces for isogeometric analysis based on spline manifolds

, 2015
Based on spline manifolds we introduce and study a mathematical framework for analysis-suitable unstructured B-spline spaces. In this setting the parameter domain has a manifold structure, which allows for the definition of function spaces that have a ...
Sangalli, Giancarlo, Takacs, Thomas, Vázquez, Rafael   +2 more
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

A hospital cost analysis of a fibrin sealant patch in soft tissue and hepatic surgical bleeding

ClinicoEconomics and Outcomes Research, 2016
Mitra Corral,1 Nicole Ferko,2 Andrew Hogan,2 Sarah S Hollmann,2 Gaurav Gangoli,1 Nadine Jamous,3 Jonathan Batiller,1 Richard Kocharian1 1Ethicon BioSurgery, Somerville, NJ, USA; 2Cornerstone Research Group, Burlington, ON, Canada; 3Ethicon Biosurgery ...
Corral M, Ferko N, Hogan A, Hollmann SS, Gangoli G, Jamous N, Batiller J, Kocharian R   +7 more
doaj  

Experimental Study on Influence of Different Patterns of an Emergent Vegetation Patch on the Flow Field and Scour/Deposition Processes in the Wake Region

Water Resources Research
Flume experiments were conducted to comprehend the impact of different patterns of an emergent vegetation patch on the flow field and the scour process in natural rivers.
Oral Yagci, V. S. Özgur Kirca, Vasileios Kitsikoudis, Catherine A. M. E. Wilson, M. Furkan Celik, Caner Sertkan   +5 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Efficacy of 13.3 mg/24 h versus 4.6 mg/24 h rivastigmine patch on activities of daily living in severe Alzheimer’s disease

SAGE Open Medicine, 2014
Objective: Investigate efficacy of 13.3 mg/24 h rivastigmine patch in patients with severe Alzheimer’s disease on Alzheimer’s Disease Cooperative Study–Activities of Daily Living Scale–Severe Impairment Version items and domains.
Joseph L Micca, James E Galvin, Drew M Velting, Xiangyi Meng   +3 more
doaj   +1 more source

Cantilever Plate Mid-Span Patch Method for Dynamically Testing the In-Plane Poisson's Ratio of Oriented Strand Board

BioResources, 2023
A cantilever plate span-to-span patch method was proposed and demonstrated for dynamic testing of OSB Poisson's ratio with high testing accuracy, simplicity, ease of implementation, and effectiveness.
Yuying Zou, Zheng Wang, Yifan Zhang, Yuhao Zhou, Zhaoyu Shen   +4 more
doaj   +2 more sources

Effect of 3D Roughness Patch on Instability Amplification in a Supersonic Boundary Layer [PDF]

Surface roughness is known to have a substantial impact on the aerothermodynamic loading of high-speed vehicles, particularly via its influence on the laminar-turbulent transition process within the boundary layer.
Duan, Lian, Li, Fei, Paredes, Pedro
core   +1 more source