Results 51 to 60 of about 752,311 (360)

Autonomous patch-clamp robot for functional characterization of neurons in vivo: development and application to mouse visual cortex.

Journal of Neurophysiology, 2019
Patch clamping is the gold standard measurement technique for cell-type characterization in vivo, but it has low throughput, is difficult to scale, and requires highly skilled operation.
G. Holst, William Stoy, Bo Yang, I. Kolb, S. Kodandaramaiah, Lu Li, U. Knoblich, Hongkui Zeng, B. Haider, E. Boyden, C. Forest   +10 more
semanticscholar   +1 more source

Progress in automating patch clamp cellular physiology

Brain and Neuroscience Advances, 2018
Patch clamp electrophysiology has transformed research in the life sciences over the last few decades. Since their inception, automatic patch clamp platforms have evolved considerably, demonstrating the capability to address both voltage- and ligand ...
Luca A. Annecchino, S. Schultz
semanticscholar   +1 more source

Sustained synchronized neuronal network activity in a human astrocyte co-culture system [PDF]

, 2016
Impaired neuronal network function is a hallmark of neurodevelopmental and neurodegenerative disorders such as autism, schizophrenia, and Alzheimer's disease and is typically studied using genetically modified cellular and animal models.
Brône, Bert, Cik, Miroslav, De Vos, Winnok, Detrez, Jan R, Diels, Annick, Kuijlaars, Jacobine, Meert, Theo, Meneghello, Giulia, Nuydens, Rony, Oyelami, Tutu, Peeters, Pieter J, Rohrbacher, Jutta, Tuefferd, Marianne, Verheyen, An, Verschuuren, Marlies, Verstraelen, Peter, Versweyveld, Sofie   +16 more
core   +1 more source

Single-channel measurements of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli [PDF]

, 2012
NanC is an Escherichia coli outer membrane protein involved in sialic acid (Neu5Ac, i.e., N-acetylneuraminic acid) uptake. Expression of the NanC gene is induced and controlled by Neu5Ac. The transport mechanism of Neu5Ac is not known.
Eisenberg, Bob, Giri, Janhavi, Peneff, Caroline M., Tang, John M., Wirth, Christophe   +4 more
core   +1 more source

Patch-clamp amplifiers on a chip [PDF]

Journal of Neuroscience Methods, 2010
We present the first, fully integrated, two-channel implementation of a patch-clamp measurement system. With this "PatchChip" two simultaneous whole-cell recordings can be obtained with rms noise of 8pA in a 10kHz bandwidth. The capacitance and series-resistance of the electrode can be compensated up to 10pF and 100MΩ respectively under computer ...
P. Weerakoon, Youshan Yang, Fred J. Sigworth, Joseph Santos-Sacchi, Peter J. Kindlmann, Eugenio Culurciello   +5 more
openaire   +3 more sources

Dynamic clamp with StdpC software [PDF]

, 2011
Dynamic clamp is a powerful method that allows the introduction of artificial electrical components into target cells to simulate ionic conductances and synaptic inputs.
A Szücs, A Szücs, A Szücs, A Szücs, AA Prinz, AA Sharp, AA Sharp, AD Dorval, AI Selverston, AJ Preyer, C Muñiz, C Muñiz, CJ Kros, DW Wheeler, Dávid Samu, EI Watanabe, G Berecki, György Kemenes, HDI Abarbanel, HP Robinson, HPC Robinson, Ildikó Kemenes, J-M Goaillard, JC Bettencourt, JP Horn, JS Rothman, K Staras, Kevin Staras, L Oltedal, LS Milescu, Michael Crossley, MN Economo, NS Desai, OP Hamill, P Chamorro, PHM Kullmann, R Bertram, R Brette, R Brette, R Wilders, R Wilders, RC Elson, RD Pinto, RJ Butera Jr., S Song, T Branco, T Nowotny, T Nowotny, TA Kinard, Thomas Nowotny, TI Netoff, Vincenzo Marra   +51 more
core   +1 more source

Dendritic patch-clamp recording

Nature Protocols, 2006
The patch-clamp technique allows investigation of the electrical excitability of neurons and the functional properties and densities of ion channels. Most patch-clamp recordings from neurons have been made from the soma, the largest structure of individual neurons, while their dendrites, which form the majority of the surface area and receive most of ...
Davie, Jenny, Kole, Maarten, Letzkus, Johannes, Rancz, Ede A, Spruston, Nelson, Stuart, Gregory J, Hausser, Michael   +6 more
openaire   +5 more sources

3D bioprinted human cortical neural constructs derived from induced pluripotent stem cells [PDF]

, 2019
Bioprinting techniques use bioinks made of biocompatible non-living materials and cells to build 3D constructs in a controlled manner and with micrometric resolution.
Benedetti, Maria Cristina, Brighi, Carlo, Colosi, Cristina, Di Angelantonio, Silvia, Ghirga, Silvia, Rosa, Alessandro, Rosito, Maria, Salaris, Federico, Soloperto, Alessandro, Turris, Valeria de   +9 more
core   +1 more source

Datasets for calcium dynamics comparison between the whole-cell and a β-escin based perforated patch configuration in brain slices from adult mice

Data in Brief, 2021
Multiple processes shape calcium signals in neurons. The spatial and temporal dynamics of these signals are determined by various cellular parameters, including the calcium influx, calcium buffering, and calcium extrusion.
Simon Hess, Christophe Pouzat, Peter Kloppenburg   +2 more
doaj  

Development of GABAergic and glycinergic transmission in the neonatal rat dorsal horn [PDF]

, 2004
Cutaneous spinal sensory transmission appears to lack inhibitory control in the newborn spinal cord, but the properties of GABAergic and glycinergic synapses in the neonatal dorsal horn have not been characterized.
Baccei, ML, Fitzgerald, M
core   +1 more source