Results 51 to 60 of about 152,269 (192)

Patch clamp-assisted single neuron lipidomics

Scientific Reports, 2017
Our understanding of the physiological and pathological functions of brain lipids is limited by the inability to analyze these molecules at cellular resolution.
Collin B. Merrill, Abdul Basit, Andrea Armirotti, Yousheng Jia, Christine M. Gall, Gary Lynch, Daniele Piomelli   +6 more
doaj   +1 more source

A transistor model for the cystic fibrosis transmembrane conductance regulator

Biophysical Reports, 2023
In this paper we present a transistor circuit model for cystic fibrosis transmembrane conductance regulator (CFTR) that seeks to map the functional form of CFTR both in wild type and mutants.
William D. Hunt, Nael A. McCarty, Eduardo Martinez Marin, Ryan S. Westafer, Phillip R. Yamin, Guiying Cui, Andrew W. Eckford, Douglas R. Denison   +7 more
doaj   +1 more source

Sustained synchronized neuronal network activity in a human astrocyte co-culture system [PDF]

, 2016
Impaired neuronal network function is a hallmark of neurodevelopmental and neurodegenerative disorders such as autism, schizophrenia, and Alzheimer's disease and is typically studied using genetically modified cellular and animal models.
Brône, Bert, Cik, Miroslav, De Vos, Winnok, Detrez, Jan R, Diels, Annick, Kuijlaars, Jacobine, Meert, Theo, Meneghello, Giulia, Nuydens, Rony, Oyelami, Tutu, Peeters, Pieter J, Rohrbacher, Jutta, Tuefferd, Marianne, Verheyen, An, Verschuuren, Marlies, Verstraelen, Peter, Versweyveld, Sofie   +16 more
core   +1 more source

Dynamic clamp with StdpC software [PDF]

, 2011
Dynamic clamp is a powerful method that allows the introduction of artificial electrical components into target cells to simulate ionic conductances and synaptic inputs.
A Szücs, A Szücs, A Szücs, A Szücs, AA Prinz, AA Sharp, AA Sharp, AD Dorval, AI Selverston, AJ Preyer, C Muñiz, C Muñiz, CJ Kros, DW Wheeler, Dávid Samu, EI Watanabe, G Berecki, György Kemenes, HDI Abarbanel, HP Robinson, HPC Robinson, Ildikó Kemenes, J-M Goaillard, JC Bettencourt, JP Horn, JS Rothman, K Staras, Kevin Staras, L Oltedal, LS Milescu, Michael Crossley, MN Economo, NS Desai, OP Hamill, P Chamorro, PHM Kullmann, R Bertram, R Brette, R Brette, R Wilders, R Wilders, RC Elson, RD Pinto, RJ Butera Jr., S Song, T Branco, T Nowotny, T Nowotny, TA Kinard, Thomas Nowotny, TI Netoff, Vincenzo Marra   +51 more
core   +1 more source

Nanotechnology: new opportunities for the development of patch‐clamps

Journal of Nanobiotechnology, 2021
The patch-clamp technique is one of the best approaches to investigate neural excitability. Impressive improvements towards the automation of the patch-clamp technique have been made, but obvious limitations and hurdles still exist, such as ...
Jia Gao, Chunyang Liao, Sijin Liu, Tian Xia, Guibin Jiang   +4 more
doaj   +1 more source

Permissive and nonpermissive channel closings in CFTR revealed by a factor graph inference algorithm

Biophysical Reports, 2022
The closing of the gated ion channel in the cystic fibrosis transmembrane conductance regulator can be categorized as nonpermissive to reopening, which involves the unbinding of ADP or ATP, or permissive, which does not.
Alexander S. Moffett, Guiying Cui, Peter J. Thomas, William D. Hunt, Nael A. McCarty, Ryan S. Westafer, Andrew W. Eckford   +6 more
doaj   +1 more source

Influence of Global and Local Membrane Curvature on Mechanosensitive Ion Channels: A Finite Element Approach

Membranes, 2016
Mechanosensitive (MS) channels are ubiquitous molecular force sensors that respond to a number of different mechanical stimuli including tensile, compressive and shear stress.
Omid Bavi, Charles D. Cox, Manouchehr Vossoughi, Reza Naghdabadi, Yousef Jamali, Boris Martinac   +5 more
doaj   +1 more source

Single-channel recordings from cultured human retinal pigment epithelial cells. [PDF]

, 1988
We have applied patch-clamp techniques to on-cell and excised-membrane patches from human retinal pigment epithelial cells in tissue culture. Single-channel currents from at least four ion channel types were observed: three or more potassium-selective ...
Fain, GL, Fox, JA, Pfeffer, BA
core  

The Circadian Clock Gene Period1 Connects the Molecular Clock to Neural Activity in the Suprachiasmatic Nucleus. [PDF]

, 2015
The neural activity patterns of suprachiasmatic nucleus (SCN) neurons are dynamically regulated throughout the circadian cycle with highest levels of spontaneous action potentials during the day.
Block, Gene D, Colwell, Christopher S, Kudo, Takashi   +2 more
core   +1 more source

Searching for New Leads to Treat Epilepsy: Target-Based Virtual Screening for the Discovery of Anticonvulsant Agents [PDF]

, 2018
The purpose of this investigation is to contribute to the development of new anticonvulsant drugs to treat patients with refractory epilepsy. We applied a virtual screening protocol that involved the search into molecular databases of new compounds and ...
Bruno Blanch, Luis Enrique, Enrique, Nicolás Jorge, Gavernet, Luciana, Goicoechea, Sofia, Martín, Pedro, Milesi, Verónica, Palestro, Pablo Hernán, Sabatier, Laureano Leonel, Villalba, Maria Luisa   +8 more
core   +2 more sources