Cantu syndrome–associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-of-function by differential mechanisms [PDF]
, 2018 The complex disorder Cantu syndrome (CS) arises from gainof-function mutations in either KCNJ8 or ABCC9, the genes encoding the Kir6.1 and SUR2 subunits of ATP-sensitive potassium (KATP) channels, respectively. Recent reports indicate that such mutations
Grange, Dorothy K. +7 more
core +2 more sources
Depolarization of sperm membrane potential is a common feature of men with subfertility and is associated with low fertilization rate at IVF [PDF]
, 2016 STUDY QUESTION. Are significant abnormalities in outward (K+) conductance and resting membrane potential (Vm) present in the spermatozoa of patients undertaking IVF and ICSI and if so, what is their functional effect on fertilization success?
Barratt, Christopher L. R. +9 more
core +6 more sources
Evaluation of Optogenetic Electrophysiology Tools in Human Stem Cell-Derived Cardiomyocytes
Frontiers in Physiology, 2017 Current cardiac drug safety assessments focus on hERG channel block and QT prolongation for evaluating arrhythmic risks, whereas the optogenetic approach focuses on the action potential (AP) waveform generated by a monolayer of human cardiomyocytes ...
Susann Björk +7 more
doaj +1 more source
, 1977 A surface of an article adapted for relative motion with a fluid environment is finished by coating the surface with a fluid adhesive. The adhesive is covered with a sheet of flexible film material under tension, and the adhesive is set while maintaining
Fehrenkamp, L. G. +3 more
core +1 more source
Allosteric modulation of retinal GABA receptors by ascorbic acid [PDF]
, 2011 Ionotropic GABA receptors (GABAA and GABAC) belong to the Cys-loop receptor family of ligand-gated ion channels. GABAC receptors are highly expressed in the retina, mainly localized at the axon terminals of bipolar cells.
Aguayo, Luis G. +5 more
core +1 more source
Desktop Software for Patch-Clamp Raw Binary Data Conversion and Preprocessing
Journal of Electrical and Computer Engineering, 2011 Since raw data recorded by patch-clamp systems are always stored in binary format, electrophysiologists may experience difficulties with patch clamp data preprocessing especially when they want to analyze by custom-designed algorithms.
Ning Zhang +5 more
doaj +1 more source
Patch-Clamp Analysis of the Mitochondrial H+ Leak in Brown and Beige Fat
Frontiers in Physiology, 2020 Mitochondria convert the chemical energy of metabolic substrates into adenosine triphosphate (ATP) and heat. Although ATP production has become a focal point of research in bioenergetics, mitochondrial thermogenesis is also crucial for energy metabolism.
Ambre M. Bertholet, Yuriy Kirichok
doaj +1 more source
Communications Biology, 2022 An altered automated patch-clamp (APC) approach enables high-throughput recordings from native pig cardiomyocytes and human iPSC-derived cardiomyocytes.
Fitzwilliam Seibertz +10 more
doaj +1 more source
Modulation of a sustained calcium current by intracellular pH in horizontal cells of fish retina. [PDF]
, 1993 A sustained high voltage-activated (HVA), nifedipine- and cadmium-sensitive calcium current and a sustained calcium action potential (AP) were recorded from horizontal cells isolated from catfish retina.
Copenhagen, DR, Dixon, DB, Takahashi, K
core
Development of GABAergic and glycinergic transmission in the neonatal rat dorsal horn [PDF]
, 2004 Cutaneous spinal sensory transmission appears to lack inhibitory control in the newborn spinal cord, but the properties of GABAergic and glycinergic synapses in the neonatal dorsal horn have not been characterized.
Baccei, ML, Fitzgerald, M
core +1 more source