Results 71 to 80 of about 152,269 (192)

Sex‐specific activation of SK current by isoproterenol facilitates action potential triangulation and arrhythmogenesis in rabbit ventricles [PDF]

, 2018
Sex has a large influence on cardiac electrophysiological properties. Whether sex differences exist in apamin‐sensitive small conductance Ca2+‐activated K+ (SK) current (IKAS) remains unknown.
Chen, Mu, Chen, Peng-Sheng, Chen, Zhenhui, Everett, Thomas H., IV, Guo, Shuai, Lin, Shien-Fong, Rubart-von der Lohe, Michael, Wang, Zhuo, Weiss, James N., Xu, Dong-Zhu, Yin, Dechun   +10 more
core   +1 more source

Setting up a new gold standard: automated temperature-controlled hERG test on Patchliner®

Frontiers in Pharmacology, 2012
In the present study, the Patchliner® temperature-controlled automated patch clamp system was evaluated for testing actions of drugs on K+ currents through hERG channels expressed in CHO cells at 35-37°C.
Liudmila ePolonchuk
doaj   +1 more source

Human sperm ion channel (dys)function:implications for fertilization [PDF]

, 2019
BACKGROUND: Intensive research on sperm ion channels has identified members of several ion channel families in both mouse and human sperm. Gene knock-out studies have unequivocally demonstrated the importance of the calcium and potassium conductances in ...
Barratt, Christopher L. R., Brown, Sean G., Martins da Silva, Sarah J., Publicover, Stephen J.   +3 more
core   +4 more sources

Reducing agents facilitate membrane patch seal integrity and longevity

Channels
The patch clamp method is a widely applied electrophysiological technique used to understand ion channel activity and cellular excitation. The formation of a high resistance giga-ohm seal is required to obtain high-quality recordings but can be ...
Damayantee Das, Anson Wong, Timothy N. Friedman, Bradley J Kerr, Harley T. Kurata, Shawn M. Lamothe   +5 more
doaj   +1 more source

From understanding cellular function to novel drug discovery: the role of planar patch-clamp array chip technology

Frontiers in Pharmacology, 2011
All excitable cell functions rely upon ion channels that are embedded in their plasma membrane. Perturbations of ion channel structure or function result in pathologies ranging from cardiac dysfunction to neurodegenerative disorders.
Christophe ePy, Marzia eMartina, Gerardo A Diaz-Quijada, Collin C Luk, Dolores eMartinez, Mike W Denhoff, Anne eCharrier, Tanya eComas, Robert eMonette, Anthony eKrantis, Naweed I Syed, Geoffrey A.R. Mealing   +11 more
doaj   +1 more source

Atrial fibrillation and electrophysiology in transgenic mice with cardiac-restricted overexpression of FKBP12 [PDF]

, 2019
Cardiomyocyte-restricted overexpression of FK506-binding protein 12 transgenic (αMyHC-FKBP12) mice develop spontaneous atrial fibrillation (AF). The aim of the present study is to explore the mechanisms underlying the occurrence of AF in αMyHC-FKBP12 ...
Ai, Tomohiko, Chang, Po-Cheng, Chen, Hanying, Chen, Peng-Sheng, Fishbein, Michael C., Homsi, Mohamed, Li, Bai-Yan, Lin, Shien-Fong, Liu, Jijia, Liu, Ying, Maruyama, Mitsunori, Pan, Zhenwei, Rubart, Michael, Shou, Weinian, Xiao, Deyong   +14 more
core   +1 more source

Patch Clamp for MoS2 Layer‐Dependent Hydrogen Evolution Reaction

ChemElectroChem
Conventional electrochemical experiments can only obtain the average contribution of all active sites in the catalyst. Hence, it is meaningful to distinguish the electrochemical contribution of the local active sites in single‐crystal catalysts.
Zhipeng Zhang, Kuan Zhai, Junhong Chen, Chunhua Han, Yuehua Wen, Yuhang Chen, Yadi Zhou, Jiayi Chen, Xiaobin Liao, Shumin Chen, Mengyu Yan   +10 more
doaj   +1 more source

Unattended Drug Discovery Screening Workflow in a 384-Well Automated Patch Clamp System [PDF]

, 2021
Nina Brinkwirth, Alison Obergrussberger, Nadine Becker, Tim Strassmaier, James Costantin, Claudia Haarmann, Rodolfo Haedo, Niels Fertig, Sonja Stoelzle‐Feix   +8 more
openalex   +1 more source

Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide [PDF]

, 2001
Background: The sulfonylurea glibenclamide (Glib) abolishes the cardioprotective effect of ischemic preconditioning (IP), presumably by inhibiting mitochondrial KATP channel opening in myocytes. Glimepiride (Glim) is a new sulfonylurea reported to affect
Baxter, G.F., Lawrence, C.L., Maddock, H.L., Mocanu, M.M., Standen, N.B., Yellon, D.M.   +5 more
core  

Position of Premature Termination Codons Determines Susceptibility of hERG Mutations to Nonsense-Mediated mRNA Decay in Long QT Syndrome

, 2014
The degradation of human ether-a-go-go-related gene (hERG, KCNH2) transcripts containing premature termination codon (PTC)mutations by nonsense-mediatedmRNA decay (NMD) is an importantmechanismof long QT syndrome type 2 (LQT2).
Gong, Qiuming, Stump, Matthew R., Zhou, Zhengfeng   +2 more
core   +1 more source