Results 71 to 80 of about 752,311 (360)
Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going?
Advanced Biology, EarlyView.Local anesthetics (LAs), widely used in anesthesia, may also play a role in cancer treatment by inhibiting tumor growth, reducing metastasis, and enhancing immune responses. They modulate key pathways like AKT/mTOR and RAS/ERK while affecting angiogenesis and tumor innervation and the immune response.
Eduardo Nunez‐Rodriguez +3 more
wiley +1 more source
Cleaning patch-clamp pipettes for immediate reuse
Scientific Reports, 2016 Patch-clamp recording has enabled single-cell electrical, morphological and genetic studies at unparalleled resolution. Yet it remains a laborious and low-throughput technique, making it largely impractical for large-scale measurements such as cell type ...
I. Kolb +5 more
semanticscholar +1 more source
Advanced Engineering Materials, EarlyView.A new experimental setup, incorporating digital image correlation and infrared thermography in combination with inductive‐conductive heating for precise temperature control, is used to analyze the mechanical behavior and microstructural changes of sheet metal under complex thermomechanical test conditions that represent quench and partitioning ...
Christian Illgen +4 more
wiley +1 more source
Membranes, 2016 Mechanosensitive (MS) channels are ubiquitous molecular force sensors that respond to a number of different mechanical stimuli including tensile, compressive and shear stress.
Omid Bavi +5 more
doaj +1 more source
Allosteric modulation of retinal GABA receptors by ascorbic acid [PDF]
, 2011 Ionotropic GABA receptors (GABAA and GABAC) belong to the Cys-loop receptor family of ligand-gated ion channels. GABAC receptors are highly expressed in the retina, mainly localized at the axon terminals of bipolar cells.
Aguayo, Luis G. +5 more
core +1 more source
Development of Automated Patch Clamp Technique to Investigate CFTR Chloride Channel Function
Frontiers in Pharmacology, 2017 The chloride (Cl-) channel cystic fibrosis transmembrane conductance regulator (CFTR) is defective in cystic fibrosis (CF), and mutation of its encoding gene leads to various defects such as retention of the misfolded protein in the endoplasmic reticulum,
A. Billet +3 more
semanticscholar +1 more source
Patch-Clamping Fly Brain Neurons
Cold Spring Harbor Protocols, 2022 The membrane potential of excitable cells, such as neurons and muscle cells, experiences a rich repertoire of dynamic changes mediated by an array of ligand- and voltage-gated ion channels. Central neurons, in particular, are fantastic computators of information, sensing, and integrating multiple subthreshold currents mediated by synaptic inputs and ...
Fernandez Chiappe, Florencia +1 more
openaire +3 more sources
Advanced Engineering Materials, EarlyView.This article investigates residual stress formation during single‐spot nanosecond laser ablation of stainless steel. Experimental validation and a parametric study using finite element simulations are employed to analyze thermal effects, ablation dynamics, and stress evolution.
Yutaka Tsumura +7 more
wiley +1 more source
Stem Cell Research, 2019 Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have evolved into widely used and reliable cell sources for modeling cardiovascular channelopathies and for drug safety pharmacology.
Wener Li +6 more
doaj
Cantu syndrome–associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-of-function by differential mechanisms [PDF]
, 2018 The complex disorder Cantu syndrome (CS) arises from gainof-function mutations in either KCNJ8 or ABCC9, the genes encoding the Kir6.1 and SUR2 subunits of ATP-sensitive potassium (KATP) channels, respectively. Recent reports indicate that such mutations
Grange, Dorothy K. +7 more
core +2 more sources